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Course of major depressive disorder and suicide outcome: a psychological autopsy study.

机译:严重抑郁症和自杀结果的过程:一项心理尸检研究。

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BACKGROUND: There is considerable debate as to whether suicide is more likely to occur early in the course of major depressive disorder or by cumulative risk, with an increasing risk with each subsequent major depressive episode (MDE). By considering the number of MDEs among representative suicides, we aimed to further investigate the relationship between suicide outcome and the course of major depressive disorder. METHOD: A psychological autopsy method with best informants was used to investigate 154 consecutive suicides who died in the context of a DSM-IV MDE. Proxy-based interviews were conducted by using the Structured Clinical Interview for DSM-III-R; the Structured Clinical Interview for DSM-IV Axis II; and a series of behavioral and personality-trait assessments. Second, 143 living depressed outpatients of comparable age to the suicide group were assessed for their history of MDEs. The study was conducted between 2000 and 2005. RESULTS: The distribution of MDEs among depressed suicide completerswas as follows: first MDE, 74.7%; second MDE, 18.8%; more than 2 MDEs, 6.5%. This distribution is compared to 32.9% of depressed living outpatients with a single MDE. Increased levels of hostility were associated with single MDE suicide completers. The anxious trait of harm avoidance increased among multiple MDE suicide completers. Alcohol abuse increased among first MDE suicide completers. CONCLUSIONS: Suicide in major depressive disorder is most likely to occur during the first MDE, and this appears to be related to increased levels of the impulsive-aggressive diathesis.
机译:背景:关于自杀是否更可能在重度抑郁症的早期发生或通过累积风险而发生,这引起了广泛的争论,随后的每个重度抑郁发作(MDE)的风险都在增加。通过考虑代表性自杀中MDE的数量,我们旨在进一步研究自杀结果与严重抑郁症病程之间的关系。方法:采用具有最佳知情者的心理尸检方法,调查了154例在DSM-IV MDE中死亡的连续自杀。通过使用针对DSM-III-R的结构化临床访谈进行基于代理人的访谈; DSM-IV轴II的结构化临床访谈;以及一系列的行为和性格特征评估。其次,对143名与自杀年龄相当的抑郁症活着的门诊病人进行了MDEs病史评估。该研究在2000年至2005年间进行。结果:抑郁症完成者中MDE的分布如下:第一类MDE为74.7%;第二类MDE为74.7%。第二名MDE,18.8%;超过2种MDE,6.5%。与只有MDE的抑郁活着门诊患者的32.9%相比较。敌对程度的增加与单个MDE自杀完成者有关。在多个MDE自杀完成者中,避免伤害的焦虑特征有所增加。在第一个MDE自杀完成者中,酗酒现象有所增加。结论:重度抑郁症患者最有可能在首次MDE期间发生自杀,这似乎与冲动攻击性素质的提高有关。

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