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首页> 外文期刊>The journal of clinical psychiatry >Impact of cannabis and other drugs on age at onset of psychosis.
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Impact of cannabis and other drugs on age at onset of psychosis.

机译：精神病发作时大麻和其他药物对年龄的影响。

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OBJECTIVE: The aim of this study was to investigate the relationship between age and cannabis use in patients with a first psychotic episode, and to analyze the mediating effect of comorbid use of other drugs and sex on age at onset of psychosis. METHOD: All consenting patients (aged 15 to 65 years) with a first psychotic episode needing inpatient psychiatric treatment during a 2-year period between February 1997 and January 1999 were considered, confirming a total of 131 patients. Subjects were interviewed using the Structured Clinical Interview for DSM-IV Axis I Disorders, and clinical and demographic data were collected. We used general linear models with age at onset as the response variable and survival Cox models to confirm the results. Both a multivariate linear model and the corresponding Cox model were fitted with a covariate that summarizes the most significant contributors that seemed to decrease age at onset. RESULTS: Regarding the effect of cannabis use, a significant gradual reduction on age at onset was found as dependence on cannabis increased, consisting in a decrement of 7, 8.5, and 12 years for users, abusers, and dependents, respectively, with respect to nonusers (p = .004, p < .001, and p < .001, respectively). Multivariate analysis showed a clear effect of cannabis use on age at onset, which was not explained by the use of other drugs or by gender. The finding was similar in the youngest patients, suggesting that this effect was not due to chance. CONCLUSION: The major contribution of this investigation is the independent and strong link between cannabis use and early age at onset of psychosis, and the slight or nonexistent effect of sex and comorbid substance abuse in this variable. These results point to cannabis as a dangerous drug in young people at risk of developing psychosis.
机译：目的：本研究的目的是调查首次精神病发作的患者的年龄与大麻使用之间的关系，并分析其他药物和性别的混合使用对精神病发作年龄的中介作用。方法：考虑所有在1997年2月至1999年1月的2年期间内首次住院的精神病发作且需要住院精神病治疗的同意患者（年龄15至65岁），共确诊131例患者。使用针对DSM-IV第一轴疾病的结构化临床访谈对受试者进行访谈，并收集临床和人口统计学数据。我们使用一般的线性模型，以发病年龄作为反应变量，并使用生存Cox模型来确认结果。多元线性模型和相应的Cox模型均拟合有协变量，该协变量总结了似乎会降低发病年龄的最重要因素。结果：关于大麻使用的影响，发现发病年龄显着逐渐降低，因为对大麻的依赖性增加，包括对使用者，滥用者和受抚养者的大麻减少分别为7年，8.5年和12年。非用户（分别为p = .004，p <.001和p <.001）。多变量分析显示，大麻使用对发病年龄有明显影响，这不能通过使用其他药物或性别来解释。在最年轻的患者中，这一发现是相似的，这表明这种效果并非偶然。结论：这项调查的主要贡献是精神病发作时大麻使用与年龄增长之间的独立和牢固的联系，以及在该变量中性行为和共病药物滥用的轻微或不存在影响。这些结果表明，大麻是有患精神病危险的年轻人的危险药物。

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