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首页> 外文期刊>The journal of clinical psychiatry >Does conduct disorder mediate the development of substance use disorders in adolescents with bipolar disorder? A case-control family study.
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Does conduct disorder mediate the development of substance use disorders in adolescents with bipolar disorder? A case-control family study.

机译：行为障碍会介导双相情感障碍青少年的物质使用障碍吗？病例对照家庭研究。

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BACKGROUND: Recent work has highlighted important relationships among conduct disorder (CD), substance use disorders (SUD), and bipolar disorder in youth. However, because bipolar disorder and CD are frequently comorbid in the young, the impact of CD in mediating SUD in bipolar disorder youth remains unclear. METHOD: 105 adolescents with DSM-IV bipolar disorder (mean +/- SD age = 13.6 +/- 2.50 years) and 98 controls (mean +/- SD age = 13.7 +/- 2.10 years) were comprehensively assessed with a structured psychiatric diagnostic interview for psychopathology and SUD. The study was conducted from January 2000 through December 2004. RESULTS: Among bipolar disorder youth, those with CD were more likely to report cigarette smoking and/or SUD than youth without CD. However, CD preceding SUD or cigarette smoking did not significantly increase the subsequent risk of SUD or cigarette smoking. Adolescents with bipolar disorder and CD were significantly more likely to manifest a combined alcohol plus drug use disorder compared to subjects with bipolar disorder without CD (chi(2) = 11.99, p < .001). CONCLUSIONS: While bipolar disorder is a risk factor for SUD and cigarette smoking in a sample of adolescents, comorbidity with preexisting CD does not increase the risk for SUD. Further follow-up of this sample through the full risk of SUD into adulthood is necessary to confirm these findings.
机译：背景：最近的工作突出了青少年行为障碍（CD），物质使用障碍（SUD）和躁郁症之间的重要关系。但是，由于双相情感障碍和CD在年轻人中经常并存，因此CD对介导双相情感障碍的SUD的影响尚不清楚。方法：对105名DSM-IV双相情感障碍青少年（平均+/- SD年龄= 13.6 +/- 2.50岁）和98名对照（平均+/- SD年龄= 13.7 +/- 2.10岁）进行了结构化精神病学综合评估精神病理学和SUD诊断性访谈。该研究于2000年1月至2004年12月进行。结果：在患有双相情感障碍的年轻人中，患有CD的人比没有CD的年轻人更有可能报告吸烟和/或SUD。但是，在SUD或吸烟之前使用CD并不会显着增加随后的SUD或吸烟的风险。与没有CD的双相情感障碍的受试者相比，患有双相情感障碍和CD的青少年更有可能出现合并酒精和药物滥用的疾病（chi（2）= 11.99，p <.001）。结论：虽然双相情感障碍是青少年样本中SUD和吸烟的危险因素，但合并CD并存并不会增加SUD的风险。为了证实这些发现，有必要通过对成年后SUD的全部风险进行进一步的随访。

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