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首页> 外文期刊>The journal of clinical psychiatry >Clozapine: more side effects but still the best antipsychotic.
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Clozapine: more side effects but still the best antipsychotic.

机译：氯氮平：副作用更多，但仍是最佳的抗精神病药。

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Clozapine, the gold-standard antipsychotic, has had a fascinating history. Hippius documented this history well, but, in essence, at a time when everyone believed that antipsychotic activity and extrapyramidal symptoms (EPS) were inseparable. Wander AG laboratories, Basel, Switzerland, developed clozapine, which does not produce EPS. In our initial 1974 study,2 the most memorable effect appeared to be on the nurses, who marveled at patients' improvement in the absence of EPS while being treated with clozapine. Routine treatment at that time was to increase the dose until improvement took place or EPS were noted. For someone like Haase,3 this meant subclinical EPS, ie, changes in handwriting, which he claimed correlated with the therapeutic dose. We were able to confirm Haase's findings and also showed that clozapine did not produce cramping of handwriting.
机译：黄金级抗精神病药氯氮平具有令人着迷的历史。希皮乌斯很好地记录了这段历史，但是从本质上讲，在每个人都认为抗精神病药的活动和锥体束外症状（EPS）密不可分的时候。瑞士巴塞尔的Wander AG实验室开发了不产生EPS的氯氮平。在我们1974年的最初研究中，2最令人印象深刻的影响似乎是对护士，他们对氯氮平治疗时在没有EPS的情况下对患者的改善感到惊奇。当时的常规治疗是增加剂量，直到发生改善或注意到EPS。对于像Haase [3]这样的人，这意味着亚临床EPS，即笔迹变化，他声称这与治疗剂量有关。我们能够确认Haase的发现，并且还表明氯氮平不会产生局促的笔迹。

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