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首页> 外文期刊>The journal of clinical psychiatry >Suicidal Ideation and Varenicline:A Possible Case of Mistaken Adverse Drug Reaction?
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Suicidal Ideation and Varenicline:A Possible Case of Mistaken Adverse Drug Reaction?

机译：自杀意念和缬草胺：药物不良反应的可能案例？

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Sir: Varenicline, an (alpha)_4(beta)_2 nicotinic acetylcholine partial agonist, has been licensed in the United Kingdom (and approved in the United States) for the treatment of tobacco dependence since 2006. Studies have shown varenicline to result in higher smoking cessation rates over placebo, bupropion, and nicotine replacement therapy (NRT). In the one study conducted to date, varenicline was also seen to be effective in smokers with mental illness, there being no evidence of excess adverse events or exacerbation of preexisting conditions. Craving to smoke is the symptom most predictive of relapse in the period immediately following a cessation attempt. Varenicline appears to achieve improved efficacy by more effectively reducing craving than other therapies, while being similarly effective in reducing other tobacco withdrawal symptoms, such as depression, irritability, and poor concentration.
机译：主席先生：Varenicline是一种α_4β2烟碱型乙酰胆碱部分激动剂，自2006年以来已在英国获得许可（并在美国获得批准）用于治疗烟草依赖。安慰剂，安非他酮和尼古丁替代疗法（NRT）的戒烟率。在迄今为止进行的一项研究中，伐尼克兰还被认为对患有精神疾病的吸烟者有效，没有证据表明过度的不良事件或加剧了既往病情。渴望吸烟是戒烟后立即复发的最可预测的症状。瓦伦尼克碱似乎通过比其他疗法更有效地减少了渴望而获得了提高的疗效，同时在减轻其他戒烟症状（如抑郁症，烦躁不安和注意力不集中）方面同样有效。

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