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首页> 外文期刊>The journal of clinical psychiatry >Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trials.
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Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trials.

机译：患有快速循环性双相情感障碍和近期药物滥用史的患者的临床相关性：来自2项随机，安慰剂对照试验的基线数据的亚型比较。

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OBJECTIVE: To compare clinical variables in patients with rapid-cycling bipolar I or II disorder and a recent history of substance use disorder (SUD). METHOD: Cross-sectional data from 2 studies of patients with rapid-cycling bipolar I disorder or rapid-cycling bipolar II disorder and a recent history of SUD were used to retrospectively assess the differences in clinical variables between the subtypes. The studies were conducted from November 1997 to February 2007 at University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. Extensive clinical interview and the Mini-International Neuropsychiatric Interview were used to ascertain DSM-IV diagnoses of rapid-cycling bipolar disorder, SUDs, and other Axis I disorders and to collect clinical variables. The Addiction Severity Index (ASI), Global Assessment Scale (GAS), and the Medical Outcomes Study 36-Item Short-Form Health Survey were used to measure the severity of impairment at the initial assessment. One-way analysis of variance or chi(2) was used for significance tests. A Bonferroni adjustment was applied for multiple comparisons. RESULTS: Of 245 patients with rapid-cycling bipolar disorder (rapid-cycling bipolar I disorder, N = 191; rapid-cycling bipolar II disorder, N = 54) and a recent history of SUD, the demographics were similar. A significantly higher rate of panic disorder was observed in patients with rapid-cycling bipolar I disorder than in those with rapid-cycling bipolar II disorder (odds ratio = 3.72, 95% CI = 1.66 to 8.32, p = .008). A significantly higher psychiatric composite score on the ASI was also found in patients with rapid-cycling bipolar I disorder than in those with rapid-cycling bipolar II disorder even after Bonferroni adjustment (p = .0007). There were no significant differences between the subtypes in the rates of previous hospitalization or suicide attempt, early childhood verbal, physical, or sexual abuse, lifetime substance abuse or dependence, the number of SUDs or mood episodes in the last 12 months, and total or other subscale scores on ASI and GAS. CONCLUSION: Except for the significantly higher rate of comorbid panic disorder and higher psychiatric composite scores on the ASI in patients with rapid-cycling bipolar I disorder than in those with rapid-cycling bipolar II disorder, the other clinical variables were similar between the 2 groups.
机译：目的：比较快速循环双相性I或II型躁郁症和近期药物滥用症（SUD）病史的临床变量。方法：使用两项有关快速循环双相I型障碍或快速循环双相II型障碍患者和近期SUD病史的研究的横断面数据回顾性评估亚型之间的临床变量差异。该研究于1997年11月至2007年2月在俄亥俄州克利夫兰市凯斯西储大学医学院的大学医院凯斯医学中心进行。广泛的临床访谈和Mini-International Neuropsychiatric访谈被用来确定DSM-IV对快速循环双相情感障碍，SUD和其他Axis I障碍的诊断，并收集临床变量。在初始评估时，使用成瘾严重性指数（ASI），全球评估量表（GAS）和医学成果研究36项简短健康调查来衡量损害的严重性。方差或chi（2）的单向分析用于显着性检验。将Bonferroni调整应用于多个比较。结果：245例快速骑自行车的双相情感障碍（快速骑自行车的双相I型障碍，N = 191;快速骑车的双相II型疾病，N = 54）和最近的SUD病史，人口统计学相似。在患有快速循环双相I型障碍的患者中，观察到的恐慌症患病率明显高于患有快速循环双相I型II障碍的患者（优势比= 3.72，95％CI = 1.66至8.32，p = .008）。即使在Bonferroni调整后，快速循环双相I型障碍患者的精神病综合评分也明显高于快速循环双相I型障碍患者（p = .0007）。亚型之间的先前住院或自杀未遂率，儿童早期言语，身体或性虐待，终生滥用或依赖的发生率，最近12个月SUD或情绪发作的数量，总或其他有关ASI和GAS的量表分数。结论：除了快速合并双相I型障碍的患者的合并症恐慌症的发生率和ASI的精神病综合得分均高于快速合并双相I型障碍的患者，两组的其他临床变量相似。

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