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首页> 外文期刊>The journal of clinical psychiatry >Delayed posttraumatic stress disorder: systematic review, meta-analysis, and meta-regression analysis of prospective studies.
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Delayed posttraumatic stress disorder: systematic review, meta-analysis, and meta-regression analysis of prospective studies.

机译：迟发性创伤后应激障碍：前瞻性研究的系统评价，荟萃分析和荟萃回归分析。

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OBJECTIVE: Prevalence estimates of delayed posttraumatic stress disorder (PTSD) have varied widely in the literature. This study is the first to establish the prevalence of delayed PTSD in prospective studies and to evaluate associated factors through meta-analytic techniques. DATA SOURCES: Studies were located by an electronic search using the databases EMBASE, MEDLINE, and PsycINFO. Search terms were posttraumatic stress disorder [include all subheadings] AND (delayed OR prospective OR longitudinal OR follow-up). Results were limited to journal articles published between 1980 and April 4, 2008. STUDY SELECTION: We included longitudinal, prospective studies of humans exposed to a potentially traumatic event that assessed participants at 1 to 6 months after the event, that included a follow-up of at least 12 months after the event, and that specified rates of new onset and remission between assessments in study completers. DATA EXTRACTION: Data were extracted concerning the study design, demographic features, and event-related characteristics and the number of PTSD cases at first assessment, the number of PTSD cases among study dropouts, and the number of new event-related PTSD cases at each subsequent assessment among study completers. Data from 24 studies were included. Four of these provided additional data on initial subthreshold PTSD and subsequent risk of delayed PTSD. DATA SYNTHESIS: The proportion of PTSD cases with delayed PTSD was 24.8% (95% CI = 22.6% to 27.2%) after adjusting for differences in study methodology, demographic features, and event-related characteristics. Military combat exposure, Western cultural background, and lower cumulative PTSD incidence were associated with delayed PTSD. Participants with initial subthreshold PTSD were at increased risk of developing delayed PTSD. CONCLUSIONS: Delayed PTSD was found among about a quarter of PTSD cases and represents exacerbations of prior symptoms.
机译：目的：关于创伤后应激障碍（PTSD）的患病率估计在文献中差异很大。这项研究是首次在前瞻性研究中确定延迟性PTSD的患病率，并通过荟萃分析技术评估相关因素。数据来源：使用数据库EMBASE，MEDLINE和PsycINFO通过电子搜索对研究进行定位。搜索词为创伤后应激障碍[包括所有小标题] AND（延迟或预期或纵向或随访）。结果仅限于1980年至2008年4月4日之间发表的期刊文章。研究选择：我们纳入了对遭受潜在创伤事件的人进行的纵向前瞻性研究，该研究在事件发生后1至6个月对参与者进行了评估，其中包括随访事件发生后至少12个月的时间，并在研究完成者的评估之间指定新的发作和缓解率。数据提取：提取有关研究设计，人口统计学特征和事件相关特征的数据，以及初次评估时的PTSD病例数，研究退出者中的PTSD病例数，以及每个事件中新的事件相关PTSD病例数后续研究完成者之间的评估。包括来自24个研究的数据。其中四个提供了有关初始亚阈值PTSD和随后的PTSD延迟风险的更多数据。数据综合：校正研究方法，人口统计学特征和事件相关特征的差异后，PTSD延迟性PTSD病例的比例为24.8％（95％CI = 22.6％至27.2％）。军事战斗经历，西方文化背景和较低的PTSD累积发病率与PTSD延迟有关。初始PTSD低于阈值的参与者发生PTSD延迟的风险增加。结论：在约四分之一的PTSD患者中发现了PTSD延迟，代表先前症状的加重。

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