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首页> 外文期刊>The journal of clinical psychiatry >Closing the efficacy-effectiveness gap: translating both the what and the how from randomized controlled trials to clinical practice.
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Closing the efficacy-effectiveness gap: translating both the what and the how from randomized controlled trials to clinical practice.

机译：缩小疗效-效果差距：将什么和如何从随机对照试验翻译为临床实践。

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摘要

There is a well-known gap between the clinical outcomes achieved within randomized controlled trials (RCTs) and those seen in real-world clinical practice. This phenomenon, sometimes called the "efficacy-effectiveness" gap, has been cited as a potential barrier to achieving optimal benefit from available treatments. The time lag between medical discovery and routine implementation can at times be extraordinarily long (such as the 264-year gap between the first use and the routine use of lemon juice for treatment of scurvy), with current estimates suggesting an average 17-year lapse between initial publication and widespread clinical practice.4 This pattern has been demonstrated in multiple settings within health care, including psychiatry
机译：在随机对照试验（RCT）中获得的临床结果与现实世界中的临床实践之间存在着众所周知的差距。这种现象有时被称为“功效-效果”差距，被认为是从现有治疗中获得最佳收益的潜在障碍。从医学发现到例行实施之间的时间差有时可能会非常长（例如，首次使用和例行使用柠檬汁治疗坏血病之间存在264年的间隔），目前的估计表明平均间隔了17年在最初发表和广泛的临床实践之间。4这种模式已在包括精神病在内的卫生保健的多种环境中得到证明。

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