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How do you choose a second-line treatment option for depression?

机译:您如何选择抑郁症的二线治疗选择?

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A majority of patients with major depression do not remit or adequately respond to initial antidepressant therapy. When response is insufficient, a diagnosis of depression and any comorbidities should be confirmed, treatment adherence should be established, and antidepressant dosages should be optimized as tolerated. If response is still insufficient, then implementing second-line treatment strategies is warranted. Second-line strategies of switching to or combining/augmenting the initial agent with one of a variety of antidepressant medications and/or psychotherapies improves remission rates, although no single approach or agent has demonstrated clear superiority over any other. Second-line treatment selections should be driven by safety considerations, patients' symptom profiles, and patient preference. Comorbid medical conditions, especially cardiac and cerebrovascular complications, and potential drug-drug interactions should be considered when making treatment decisions.
机译:大多数重度抑郁症患者无法缓解或对最初的抗抑郁治疗没有足够的反应。当反应不足时,应确诊为抑郁症和任何合并症,应建立治疗依从性,并应根据耐受情况优化抗抑郁药剂量。如果反应仍然不足,则必须实施二线治疗策略。尽管没有任何一种方法或药物显示出明显优于其他任何药物的方法,但切换至初始药物或将其与多种抗抑郁药和/或心理疗法中的一种相结合的二线策略可改善缓解率。二线治疗的选择应基于安全考虑,患者的症状特征和患者的偏爱。在制定治疗决策时,应考虑合并疾病,尤其是心脏和脑血管并发症,以及潜在的药物相互作用。

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