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首页> 外文期刊>The journal of clinical psychiatry >A 2-year prospective follow-up study of the course of obsessive-compulsive disorder.
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A 2-year prospective follow-up study of the course of obsessive-compulsive disorder.

机译：对强迫症过程进行为期2年的前瞻性随访研究。

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BACKGROUND: Surprisingly little is known about the long-term course of obsessive-compulsive disorder (OCD). This prospective study presents 2-year course findings, as well as predictors of course, from the Brown Longitudinal Obsessive Compulsive Study, the first comprehensive prospective investigation of the observational course of OCD in a large clinical sample. METHOD: The sample included 214 treatment-seeking adults with DSM-IV OCD at intake who identified OCD as the most problematic disorder over their lifetime. Subjects were enrolled from 2001-2004. At annual interviews, data on weekly OCD symptom status were obtained using the Longitudinal Interval Follow-Up Evaluation. Probabilities of full remission and partial remission over the first 2 years of collected data and potential predictors of remission were examined. RESULTS: The probability of full remission from OCD was 0.06, and the probability of partial remission was 0.24. Of the 48 subjects whose OCD symptoms partially or fully remitted, only 1 relapsed within the first 2 years. Earlier age at onset of OCD, greater severity of symptoms at intake, older age at intake, and being male were associated with a decreased likelihood of remission. Insight, diagnostic comorbidity, and treatment were not found to be associated with the likelihood of achieving full or partial remission. CONCLUSIONS: Though one-quarter of the sample had periods of subclinical OCD symptoms during the prospective period, full remission was rare, consistent with the view of OCD as a chronic and persistent illness. Age at onset, OCD symptom severity, current age, and sex emerged as potent predictors of course.
机译：背景：关于强迫症（OCD）的长期病程知之甚少。这项前瞻性研究提供了2年课程的发现，以及课程的预测指标，来自“布朗纵向强迫症研究”，这是对大型临床样本中OCD观察过程的首次全面前瞻性研究。方法：该样本包括214名在进食时患有DSM-IV OCD的寻求治疗的成年人，他们确定OCD是一生中最有问题的疾病。研究对象从2001年至2004年入学。在年度访谈中，使用纵向间隔随访评估获得每周强迫症症状状态的数据。检查了收集的数据的前两年中完全缓解和部分缓解的可能性以及缓解的潜在预测因子。结果：OCD完全缓解的可能性为0.06，部分缓解的可能性为0.24。在强迫症症状部分或完全缓解的48位受试者中，只有1位在最初2年内复发。强迫症发作的年龄越早，摄入症状的严重性越大，摄入年龄越大以及男性，与缓解的可能性降低相关。没有发现洞察力，诊断合并症和治疗与实现全部或部分缓解的可能性相关。结论：尽管有四分之一的样本在预期期内出现亚临床强迫症症状，但完全缓解的情况很少，这与强迫症是一种慢性和持续性疾病的观点一致。发病年龄，强迫症症状严重程度，当前年龄和性别成为了有效的预测指标。

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