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首页> 外文期刊>The journal of clinical psychiatry >Comorbid alcoholism and depression: treatment issues.
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Comorbid alcoholism and depression: treatment issues.

机译：酒精中毒和抑郁症合并症：治疗问题。

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Unless there is decisive professional intervention, people who suffer from both a depressive disorder and alcoholism are at great risk of chronic impairment, both at home and in the workplace; persistent symptomatic misery; and premature death. Untreated alcoholism intensifies depressive states, decreases responsiveness to conventional therapeutics, and increases the likelihood of suicide, suicide attempts, and other self-destructive behavior. During the past decade, evidence has emerged from placebo-controlled studies supporting the utility of tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) for treatment of depressed alcoholics. The superior safety and tolerability of SSRIs provide strong justification for their first-line use despite higher drug acquisition costs. Evidence has similarly emerged concerning the use of several novel pharmacotherapies and focused psychotherapies for people with alcoholism. These newer therapeutic options complement more traditional intervention such as chemical dependence counseling, disulfiram, and Alcoholics Anonymous so that it is now possible for a majority of depressed alcoholics to be treated effectively. The availability of effective treatments provides further impetus for health care professionals to improve recognition of comorbid alcoholism and depressive disorders. Improved recognition and treatment will save lives, and the benefits are likely to extend across generations.
机译：除非有果断的专业干预，否则无论是在家中还是在工作场所，患有抑郁症和酗酒的人都极有可能遭受慢性损伤。持续的症状痛苦;和过早死亡。未经治疗的酒精中毒会加剧抑郁状态，降低对传统疗法的反应性，并增加自杀，自杀未遂和其他自残行为的可能性。在过去的十年中，来自安慰剂对照研究的证据支持三环类抗抑郁药和选择性5-羟色胺再摄取抑制剂（SSRIs）用于治疗抑郁症的酗酒者。尽管购药成本较高，但SSRI的优越安全性和耐受性为其一线使用提供了有力依据。关于酒精中毒患者使用几种新型药物治疗和重点心理治疗的证据也相似。这些较新的治疗选择补充了更传统的干预措施，例如化学依赖咨询，双硫仑和匿名戒酒者，因此现在有可能有效治疗大多数抑郁症的酗酒者。有效治疗的可利用性进一步推动了医疗保健专业人员提高对合并症，酒精中毒和抑郁症的认识。更好的识别和治疗将挽救生命，其好处可能会延续到几代人。

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