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首页> 外文期刊>The journal of clinical psychiatry >Subsyndromal depressive symptoms after symptomatic recovery from mania are associated with delayed functional recovery.
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Subsyndromal depressive symptoms after symptomatic recovery from mania are associated with delayed functional recovery.

机译：从躁狂症状恢复后的亚症状性抑郁症状与功能恢复延迟有关。

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OBJECTIVE: This study examined whether the presence of subsyndromal depressive symptoms predicted functional recovery after an acute manic episode. METHOD: Subjects with bipolar I disorder (according to the Structured Clinical Interview for DSM-IV) who, at the time of symptomatic recovery from an acute manic or hypomanic episode, had a concomitant functional recovery (n = 52) were compared on demographic variables and mood symptoms to those who had symptomatically recovered but not functionally recovered (n = 33). Demographic and mood variables were examined in the nonfunctionally recovered group to assess predictors of time to functional recovery. The primary functional outcome measure used was the Life Functioning Questionnaire, a 5-minute, gender-neutral self-report scale to measure role function in 4 domains: workplace, duties at home, leisure time with family, and leisure time with friends. Participants in the study were recruited from July 2000 through February 2005. RESULTS: Depressive symptoms, even at a subsyndromal level, were significantly associated with persisting functional impairment after symptomatic recovery from a manic episode (P < .02). Subsyndromal depressive symptoms also significantly predicted a slower time to functional recovery over the next 9 months (P = .006). CONCLUSION: The presence of even mild subsyndromal depressive symptoms may interfere with functional recovery in patients with bipolar disorder after symptomatic recovery from a manic or hypomanic episode.
机译：目的：本研究检查了亚症状性抑郁症状的存在是否可以预测急性躁狂发作后的功能恢复。方法：比较双相I障碍（根据DSM-IV的结构化临床访谈）的受试者，从急性躁狂或躁狂发作发作症状恢复时，伴随功能恢复（n = 52），并比较人口统计学变量有症状但无功能恢复者的情绪和情绪症状（n = 33）。在非功能恢复组中检查了人口统计学和情绪变量，以评估功能恢复时间的预测指标。使用的主要功能结局指标是生活功能问卷，这是一个5分钟，不分性别的自我报告量表，用于测量4个领域中的角色功能：工作场所，在家工作，与家人休闲时间和与朋友休闲时间。该研究的参与者于2000年7月至2005年2月间招募。结果：抑郁症状，即使在亚综合征水平，也与躁狂发作症状恢复后持续的功能障碍显着相关（P <.02）。亚综合征性抑郁症状还显着预测了未来9个月内功能恢复的时间会变慢（P = .006）。结论：躁狂或躁狂发作症状恢复后，双相情感障碍患者甚至出现轻度的综合征下抑郁症状也可能干扰其功能恢复。

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