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首页> 外文期刊>The journal of clinical psychiatry >Clinical features of treatment-resistant depression.
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Clinical features of treatment-resistant depression.

机译：抗抑郁药的临床特征。

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摘要

As many as 30% to 40% of patients with major depressive disorder are unresponsive to a trial of antidepressant medication. Many patients labeled with treatment-resistant depression actually have pseudoresistance, in that they have been inadequately treated or are misdiagnosed. Others may have unrecognized comorbid psychiatric or general medical conditions that contribute to treatment resistance. Variables such as gender, family history, age at onset, severity, and chronicity have also been evaluated as possible risk factors for treatment-resistant depression. This article reviews the current literature regarding the clinical characteristics of treatment-resistant depression, with particular attention to the relevance of these factors for clinical decision making.
机译：多达30％至40％的重度抑郁症患者对抗抑郁药物的试验无反应。许多标有抗治疗性抑郁症的患者实际上具有假抗性，因为他们没有得到充分的治疗或被误诊。其他人则可能患有无法识别的合并精神病或一般医学状况，从而增加了治疗抵抗力。诸如性别，家族病史，发病年龄，严重程度和慢性病等变量也已被评估为抗药性抑郁症的可能危险因素。本文回顾了有关抗药性抑郁症临床特征的最新文献，特别关注这些因素与临床决策的相关性。

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