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Mechanisms of antipsychotic-induced weight gain.

机译:抗精神病药诱发体重增加的机制。

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摘要

The estimated percentage of persons with schizophrenia who are overweight is higher than the percentage of persons in the general population who are overweight. The increased mortality rate for persons with schizophrenia is largely due to obesity-related diseases. The atypical antipsychotics offer an improved therapeutic index when compared with the conventional agents, but may impart serious adverse events such as weight gain. This brief review is intended to provide the practicing clinician with an update of disparate research paradigms under investigation in an attempt to delineate the biological mechanisms that presage weight gain. Research success in this area may invite novel prevention strategies and hint at potential mechanisms of antipsychotic drug action.
机译:超重的精神分裂症患者的估计百分比高于超重的普通人群中的百分比。精神分裂症患者的死亡率增加主要是由于肥胖相关疾病。与常规药物相比,非典型抗精神病药具有更高的治疗指数,但可能带来严重的不良事件,例如体重增加。这篇简短的综述旨在为临床医生提供正在研究的不同研究范例的最新信息,以期勾勒出预示体重增加的生物学机制。该领域的研究成功可能会提出新颖的预防策略,并暗示抗精神病药物作用的潜在机制。

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