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首页> 外文期刊>The journal of clinical psychiatry >Risperidone added to clozapine: impact on serum prolactin levels.
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Risperidone added to clozapine: impact on serum prolactin levels.

机译：利培酮添加到氯氮平中：对血清催乳素水平的影响。

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BACKGROUND: Several years ago, we reported that the addition of risperidone to clozapine improved response in some patients with schizophrenia. Risperidone, in general, is well tolerated when administered as monotherapy, but has been linked to a persistent elevation of serum prolactin and associated symptoms. The goal of this study was to determine whether the addition of risperidone to clozapine results in an elevation of serum prolactin levels in patients with chronic schizophrenia or schizoaffective disorder. METHOD: Twenty patients on clozapine-risperidone combination therapy were matched for age and gender with 20 patients treated with clozapine monotherapy. Demographic information was gathered along with clozapine and risperidone dose and the length of time on risperidone. Serum prolactin levels were measured from a single blood sample. RESULTS: The 2 groups did not differ in age, race, gender, diagnosis, age at clozapine initiation, age at onset, Abnormal Involuntary Movement Scale scores, or clozapine dose. The mean +/- SD serum prolactin level was 8.42+/-4.17 ng/mL for clozapine monotherapy patients and 35.76+/-17.43 ng/mL for combination therapy patients. The 2 medication categories showed a significant difference in log prolactin values (t = -7.97, df = 38, p < or = .0001). Sixteen combination therapy patients (80%) exhibited elevated prolactin levels (range for entire group, 9.7-69.8 ng/mL) while only 2 clozapine monotherapy patients (10%) exhibited prolactin elevation levels (range for entire group, 2.4-20.2 ng/mL; df = 1, p < .0001). CONCLUSION: The combination of risperidone and clozapine appears to result in a moderate elevation of serum prolactin levels. Additionally, controlled prospective studies are needed to clarify the risks of long-term elevations of serum prolactin level.
机译：背景：几年前，我们报道了在氯氮平中加入利培酮可以改善某些精神分裂症患者的反应。通常，利培酮作为单药治疗时耐受性良好，但与血清催乳素持续升高和相关症状有关。这项研究的目的是确定在慢性精神分裂症或精神分裂症患者中向氯氮平中添加利培酮是否会导致血清催乳素水平升高。方法：将20例接受氯氮平-利培酮联合治疗的患者按年龄和性别进行匹配，其中20例接受氯氮平单药治疗的患者。人口统计信息与氯氮平和利培酮剂量以及使用利培酮的时间长度一起收集。从单个血样中测量血清催乳素水平。结果：两组在年龄，种族，性别，诊断，氯氮平起始年龄，发病年龄，非自愿运动量表评分或氯氮平剂量方面无差异。氯氮平单药患者的平均+/- SD血清催乳素水平为8.42 +/- 4.17 ng / mL，联合治疗患者为35.76 +/- 17.43 ng / mL。 2种药物类别的对催乳激素值显示出显着差异（t = -7.97，df = 38，p <或= .0001）。 16名联合治疗患者（80％）的泌乳素水平升高（整个组范围为9.7-69.8 ng / mL），而只有2例氯氮平单药治疗患者（10％）的泌乳素水平升高（整个组范围为2.4-20.2 ng / mL） mL; df ＝ 1，p ＜.0001）。结论：利培酮和氯氮平联用可导致血清催乳素水平适度升高。另外，需要进行对照的前瞻性研究来阐明血清催乳素水平长期升高的风险。

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