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Dr Preskorn replies

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Preskorn and colleagues1 reported on an impressively large population-based study among 900 patients who recently started venlafaxine treatment and who were both genotyped and phenotyped for cytochrome P450 (CYP) 2D6 metabolism. Among these patients, 3.9% and 27.0%, respectively, were genotyped and phenotyped as a poor metabolizer. The investigators inferred that "personalized medicine solely based on genetics can be misleading."(~p614) Although we agree with this statement, some issues could have been addressed more extensively to underscore the need for pharmacogenetics.

机译：Preskorn及其同事1在一项基于人群的研究中报告了一项令人印象深刻的大规模研究，研究对象是900位最近开始接受文拉法辛治疗且同时具有细胞色素P450（CYP）2D6代谢基因型和表型的患者。在这些患者中，基因型和表型分别为不良代谢者，分别为3.9％和27.0％。研究人员推断“仅基于遗传学的个性化医学可能会产生误导。”（〜p614）尽管我们同意这一说法，但某些问题本来可以得到更广泛的解决，以强调对药物遗传学的需求。

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《The journal of clinical psychiatry》 |2013年第10期|共2页
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