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The relationship between bipolar disorder and biological rhythms

机译：躁郁症与生物节律的关系

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Background: Rhythm disruption is a core feature of bipolar disorder and it has been hypothesized that disturbances of the circadian timing system play a fundamental role in the etiology of the disorder. Objective: We sought to investigate (1) theoretical models for biological rhythm disruptions in bipolar disorde (2) physiological disturbances of biological rhythms in bipolar disorder, (3) clinical and therapeutic implications of biological rhythm disturbances in bipolar disorder, and (4) associations between circadian gene variations and bipolar disorder DataSources: PubMed database was searched systematically for articles that were published on or before May 5, 2013, and were written in English using the terms bipolardisorder, clock genes, endogenous clock, molecular clock, biological rhythms, circadian, suprachiasmatic nucleus, circadian rhythm, melatonin, and sleep. Study Selection: Seventy-four articles highlighting the objectives were included in the review. Data Extraction: Data regarding exploring the association between bipolar disorder and circadian and chronobiological phenomena were reviewed and findings summarized. Results:The literature reviewed suggests that circadian rhythm disturbance may be a feature of bipolar disorder Conclusions: In toto, the literature suggests that circadian rhythm disturbances may be a feature of bipolar disorderlhis area of research has received theoretical consideration as playing a significant role in the pathophysiology of the illness but has been understudied to this point. Further research in the field is warranted.
机译：背景：节律紊乱是双相情感障碍的核心特征，据推测，昼夜节律系统的紊乱在该病的病因中起着基本作用。目的：我们试图研究（1）躁郁症的生物节律紊乱的理论模型（2）躁郁症的生物节律的生理紊乱，（3）躁郁症的生物节律的临床和治疗意义，以及（4）协会昼夜节律基因变异与双相情感障碍之间的关系数据来源：在PubMed数据库中系统搜索了2013年5月5日或之前发表的文章，并使用双相情感障碍，时钟基因，内源性时钟，分子时钟，生物节律，昼夜节律用英语撰写，视交叉上核，昼夜节律，褪黑激素和睡眠。研究选择：综述中共有74篇强调目标的文章。数据提取：回顾了有关探索躁郁症与昼夜节律和时间生物学现象之间关系的数据，并对发现进行了总结。结果：综述的文献表明，昼夜节律紊乱可能是双相情感障碍的特征结论：总体而言，文献表明，昼夜节律紊乱可能是双相情感障碍的特征。他的研究领域已受到理论考虑，因为它在双相情感障碍中起着重要作用。疾病的病理生理学至今尚未被研究。有必要在该领域进行进一步的研究。

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