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首页> 外文期刊>The journal of clinical psychiatry >An exploratory randomized controlled study of a healthy living intervention in early intervention services for psychosis: The intervention to encourage activity, improve diet, and reduce weight gain (INTERACT) study
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An exploratory randomized controlled study of a healthy living intervention in early intervention services for psychosis: The intervention to encourage activity, improve diet, and reduce weight gain (INTERACT) study

机译：对精神病早期干预服务中的健康生活干预措施的一项探索性随机对照研究：一项旨在鼓励活动，改善饮食和减轻体重的干预措施（INTERACT）研究

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Background: People with psychosis often experience weight gain, which places them at risk of cardiovascular disease, diabetes, and early death. Objective: To determine the uptake, adherence, and clinical effectiveness of a healthy living intervention designed to reduce weight gain. Method: An exploratory randomized controlled trial, comparing the intervention with treatment as usual (TAU) in 2 early intervention services for psychosis in England. DSM-IV classification was the diagnostic criteria used to assign the psychiatric diagnoses. The primary outcome was change in body mass index (BMI) from baseline to 12-month follow-up. The study was conducted between February 2009 and October 2012. Results: 105 service users, with a BMI of ≥ 25 (≥ 24 in South Asians), were randomized to intervention (n = 54) orTAU (n = 51) after stratification by recent commencement of antipsychotic medication. Ninety-three service users (89%) were followed up at 12 months. Between-group difference in change in BMI was not significant (effect size = 0.11).The effect of the intervention was larger (effect size = 0.54, not significant) in 15 intervention (28%) and 10TAU (20%) participants who were taking olanzapine or clozapine at randomization. Conclusions: The healthy living intervention did not show a significant difference in BMI reduction compared to the TAU group.
机译：背景：精神病患者经常会体重增加，使他们有患心血管疾病，糖尿病和早逝的风险。目的：确定旨在减少体重增加的健康生活干预措施的摄取，依从性和临床有效性。方法：一项探索性随机对照试验，将英格兰的2种精神病早期干预服务的干预措施与常规治疗（TAU）进行了比较。 DSM-IV分类是用于分配精神病学诊断的诊断标准。主要结果是从基线到12个月随访的体重指数（BMI）的变化。该研究于2009年2月至2012年10月之间进行。结果：105名服务使用者的BMI≥25（南亚人≥24）被随机分为干预组（n = 54）或TAU（n = 51）。开始使用抗精神病药物。十二个月时有93名服务使用者（89％）得到了随访。 BMI变化的组间差异不显着（效应量= 0.11）。在15例干预（28％）和10TAU（20％）的参与者中，干预的效果更大（效应量= 0.54，不显着）随机服用奥氮平或氯氮平。结论：与TAU组相比，健康的生活干预措施在BMI降低方面无显着差异。

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