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首页> 外文期刊>The journal of clinical psychiatry >Reconsidering Dietary Polyunsaturated Fatty Acids in Bipolar Disorder: A Translational Picture
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Reconsidering Dietary Polyunsaturated Fatty Acids in Bipolar Disorder: A Translational Picture

机译：重新考虑双相情感障碍的饮食多不饱和脂肪酸：一张翻译的图片。

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摘要

Inflammation is an important mediator of pathophysiology in bipolar disorder. The omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acid (PUFA) metabolic pathways participate in several inflammatory processes and have been linked through epidemiologic and clinical studies to bipolar disorder and its response to treatment. We review the proposed role of PUFA metabolism in neuroinflammation, modulation of brain PUFA metabolism by antimanic medications in rodent models, and anti-inflammatory pharmacotherapy in bipolar disorder and in major depressive disorder (MDD). Although the convergence of findings between preclinical and postmortem clinical data is compelling, we investigate why human trials of PUFA as treatment are mixed. We view the biomarker and treatment study findings in light of the evidence for the hypothesis that arachidonic acid hypermetabolism contributes to bipolar disorder pathophysiology and propose that a combined high n-3 plus low n-6 diet should be tested as an adjunct to current medication in future trials. (C) Copyright 2016 Physicians Postgraduate Press, Inc.
机译：炎症是双相情感障碍的重要病理生理介质。 omega-3（n-3）和omega-6（n-6）多不饱和脂肪酸（PUFA）代谢途径参与多种炎症过程，并已通过流行病学和临床研究与双相情感障碍及其对治疗的反应相关。我们审查了啮齿类动物模型中PUFA代谢在神经炎症，通过抗躁狂药物调节脑部PUFA代谢以及在双相情感障碍和主要抑郁症（MDD）中使用抗炎药物治疗的作用。尽管临床前和验尸临床数据之间的发现令人信服，但我们调查了为何将PUFA作为治疗的人类试验混杂在一起。我们根据有关花生四烯酸过度代谢会导致双相情感障碍病理生理这一假说的证据，来查看生物标志物和治疗研究结果，并建议将高n-3加低n-6饮食组合作为当前药物的辅助测试。未来的审判。 （C）版权所有2016 Physicians Postgraduate Press，Inc.

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