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首页> 外文期刊>The journal of clinical psychiatry >Major depressive disorder is associated with cardiovascular risk factors and low Omega-3 Index.
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Major depressive disorder is associated with cardiovascular risk factors and low Omega-3 Index.

机译：严重的抑郁症与心血管危险因素和Omega-3指数低有关。

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OBJECTIVE: Cardiovascular disease (CVD) and major depressive disorder (MDD) are frequent worldwide and have a high comorbidity rate. Omega-3 fatty acids have been suggested as disease modulators for both CVD and MDD. Therefore, we studied whether polyunsaturated fatty acids and the Omega-3 Index may represent markers for assessment of the cardiovascular risk in somatically healthy patients suffering from MDD. METHOD: We conducted a case-control study from July 2004 to December 2007 in 166 adults (86 inpatients with MDD but without CVD from the Department of Psychiatry and Psychotherapy and 80 age- and sex-matched healthy controls from an outpatient clinic of the Division of Preventive Cardiology, Ludwig Maximilian University of Munich, Germany). Information gathered at baseline included MDD diagnosis according to DSM-IV criteria, depression ratings, conventional cardiovascular risk factors, and fatty acid and interleukin-6 determinations. Fatty acid composition was analyzed according to the HS-Omega-3 Index methodology. During the study, patients received no supplementation with omega-3 fatty acids. The main inclusion criteria were the diagnosis of MDD according to DSM-IV and a 17-item Hamilton Depression Rating Scale (HDRS-17) score of at least 17. Treatment response and remission were defined using the HDRS-17. RESULTS: Several conventional risk factors such as high triglyceride (mean, 152 mg/dL vs 100 mg/dL; P < .001) and fasting glucose (mean, 96 mg/dL vs 87 mg/dL; P = .005) values as well as greater waist circumference (mean, 97 cm vs 87 cm; P = .019) and higher body mass index (calculated as kg/m(2); mean, 26 vs 24; P = .011) were more prevalent in MDD patients in comparison with controls. The Omega-3 Index (mean, 3.9% vs 5.1%; P < .001) and individual omega-3 fatty acids were significantly lower in MDD patients. An Omega-3 Index < 4% was associated with high concentrations of the proinflammatory cytokine interleukin-6 (chi(2) = 7.8, P = .02). CONCLUSIONS: Conventional cardiovascular risk factors, the Omega-3 Index, and interleukin-6 levels indicated an elevated cardiovascular risk profile in MDD patients currently free of CVD. Our results support the employment of strategies to reduce the cardiovascular risk in still cardiovascularly healthy MDD patients by targeting conventional risk factors and the Omega-3 Index.
机译：目的：心血管疾病（CVD）和重度抑郁症（MDD）在世界范围内很常见，合并症发生率很高。有人建议将Omega-3脂肪酸作为CVD和MDD的疾病调节剂。因此，我们研究了多不饱和脂肪酸和Omega-3指数是否可以代表评估患有MDD的身体健康患者的心血管风险的标志。方法：我们从2004年7月至2007年12月对166名成人进行了病例对照研究（来自精神病学和心理治疗学系的86名MDD但没有CVD的住院患者以及来自该科门诊的80位年龄和性别相匹配的健康对照者）德国慕尼黑路德维希马克西米利安大学预防心脏病学系）。在基线收集的信息包括根据DSM-IV标准进行的MDD诊断，抑郁评分，常规心血管危险因素以及脂肪酸和白介素6的测定。根据HS-Omega-3 Index方法分析脂肪酸组成。在研究过程中，患者未补充omega-3脂肪酸。纳入的主要标准是根据DSM-IV诊断MDD，并且17个项目的汉密尔顿抑郁量表（HDRS-17）评分至少为17。使用HDRS-17定义治疗反应和缓解。结果：一些传统的危险因素，例如甘油三酸酯高（平均152 mg / dL vs 100 mg / dL; P <.001）和空腹血糖（平均96 mg / dL vs 87 mg / dL; P = .005）以及更高的腰围（平均97厘米对87厘米; P = .019）和更高的体重指数（按kg / m（2）计算;平均值为26对24; P = .011）在以下人群中更为普遍MDD患者与对照组比较。 MDD患者中的Omega-3指数（平均3.9％比5.1％; P <.001）和单独的Omega-3脂肪酸显着降低。 Omega-3指数<4％与高浓度的促炎细胞因子白介素6相关（chi（2）= 7.8，P = .02）。结论：常规心血管危险因素，Omega-3指数和白介素6水平表明，目前无CVD的MDD患者的心血管危险性升高。我们的结果支持通过针对常规危险因素和Omega-3指数降低心血管仍然健康的MDD患者的心血管风险的策略的采用。

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