...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Antidepressive treatment with monoamine oxidase inhibitors and the occurrence of intraoperative hemodynamic events: A retrospective observational cohort study
【24h】

Antidepressive treatment with monoamine oxidase inhibitors and the occurrence of intraoperative hemodynamic events: A retrospective observational cohort study

机译：单胺氧化酶抑制剂的抗抑郁治疗和术中血流动力学事件的发生：一项回顾性观察队列研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To investigate the occurrence of intraoperative hemodynamic events when antidepressive treatment with monoamine oxidase inhibitors (MAOIs) was continued during anesthesia. Method: A retrospective observational cohort study was conducted among patients who were admitted for elective surgery requiring anesthesia in 8 Dutch hospitals (2004-2010). The index group included current users of irreversible (tranylcypromine) and reversible (moclobemide) MAOIs. The reference group included a sample of nonusers matched to the index group on hospital, type and period of surgery, and type of anesthesia (ratio 1:3). The outcome of interest was the occurrence of the following intraoperative hemodynamic events: hypotension or hypertension and tachycardia or bradycardia. Results: Approximately 280,000 surgical procedures were performed in the participating hospitals in the total observational period of 33 years. The index group included 26 and 25 users of tranylcypromine and moclobemide, respectively. The reference groups included 149 nonusers. Intraoperative hypotension occurred less frequently in users of tranylcypromine (46%) than in nonusers (73%) (P = .01). The occurrence of hypertension, bradycardia, and tachycardia during anesthesia was not different between users of tranylcypromine (27%, 50%, and 12%, respectively) and those in the reference group (35%, 61%, and 26%, respectively). The occurrence of hypotension, hypertension, bradycardia, and tachycardia was not different between users of moclobemide and the reference group. Conclusions: Severe adverse hemodynamic events, such as hypertension and tachycardia, did not occur more frequently in users of both the irreversible MAOI tranylcypromine and the reversible MAO-A inhibitor moclobemide compared to nonusers. These findings suggest that there is no longer much justification to discontinue these MAOIs before surgery, with the considerable risk of compromising patients' psychiatric status.
机译：目的：探讨麻醉期间继续使用单胺氧化酶抑制剂（MAOIs）进行抗抑郁治疗时发生的术中血液动力学事件。方法：在荷兰的8家医院（2004-2010年）对接受麻醉的择期手术入院的患者进行了一项回顾性观察队列研究。索引组包括不可逆（tranylcypromine）和可逆（moclobemide）MAOI的当前使用者。参比组包括与医院，手术类型和时期以及麻醉类型等指标组相匹配的非使用者样本（比率1：3）。感兴趣的结果是以下术中血液动力学事件的发生：低血压或高血压以及心动过速或心动过缓。结果：参与观察的医院在总共33年的观察期内进行了大约280,000例外科手术。索引组分别包括26和25个使用者的tranylcypromine和moclobemide。参考组包括149个非用户。使用反式环丙胺的患者术中低血压发生的频率较低（46％），比不使用该频率的患者（73％）的发生频率低（P = 0.01）。 tranylcypromine使用者（分别为27％，50％和12％）和参考组（分别为35％，61％和26％）的使用者在麻醉期间高血压，心动过缓和心动过速的发生率没有差异。 。莫洛贝胺使用者与参考组的低血压，高血压，心动过缓和心动过速的发生率无差异。结论：与非使用者相比，不可逆MAOI tranylcypromine和可逆MAO-A抑制剂莫洛贝米德的使用者没有发生更严重的严重血液动力学事件，例如高血压和心动过速。这些发现表明，在手术前停止使用这些MAOI的理由已不复存在，而存在损害患者精神状态的巨大风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号