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首页> 外文期刊>The journal of clinical psychiatry >Intranasal Drug Delivery in Neuropsychiatry: Focus on Intranasal Ketamine for Refractory Depression
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Intranasal Drug Delivery in Neuropsychiatry: Focus on Intranasal Ketamine for Refractory Depression

机译：神经精神科鼻内药物输送：专注于鼻内氯胺酮治疗难治性抑郁症

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摘要

Intranasal drug delivery (INDD) systems offer a route to the brain that bypasses problems related to gastrointestinal absorption, first-pass metabolism, and the blood-brain barrier; onset of therapeutic action is rapid, and the inconvenience and discomfort of parenteral administration are avoided. INDD has found several applications in neuropsychiatry, such as to treat migraine, acute and chronic pain, Parkinson disease, disorders of cognition, autism, schizophrenia, social phobia, and depression. INDD has also been used to test experimental drugs, such as peptides, for neuropsychiatric indications; these drugs cannot easily be administered by other routes. This article examines the advantages and applications of INDD in neuropsychiatry; provides examples of test, experimental, and approved INDD treatments; and focuses especially on the potential of intranasal ketamine for the acute and maintenance therapy of refractory depression. (C) Copyright 2015 Physicians Postgraduate Press, Inc.
机译：鼻内药物输送（INDD）系统提供了一条通往大脑的途径，可以绕开与胃肠道吸收，首过代谢和血脑屏障有关的问题。治疗作用起效迅速，并且避免了肠胃外给药的不便和不适。 INDD已在神经精神病学中发现了多种应用，例如治疗偏头痛，急性和慢性疼痛，帕金森氏病，认知障碍，自闭症，精神分裂症，社交恐惧症和抑郁症。 INDD也已用于测试实验性药物（例如肽）的神经精神适应症。这些药物不易通过其他途径给药。本文探讨了INDD在神经精神病学中的优势和应用。提供测试，实验和批准的INDD处理的示例;尤其关注鼻内氯胺酮在难治性抑郁症的急性和维持治疗中的潜力。 （C）版权所有2015 Physicians Postgraduate Press，Inc.

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