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首页> 外文期刊>The Journal of dermatology >Vitamin D3 upregulated protein 1 (VDUP1) is a regulator for redox signaling and stress-mediated diseases.
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Vitamin D3 upregulated protein 1 (VDUP1) is a regulator for redox signaling and stress-mediated diseases.

机译：维生素D3上调蛋白1（VDUP1）是氧化还原信号传导和压力介导疾病的调节剂。

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摘要

Vitamin D(3) upregulated protein 1 (VDUP1) is a 46-kDa multifunctional protein, initially isolated in HL-60 cells as a protein of which expression is upregulated by vitamin D(3) administration. Subsequently, it was identified independently by investigators from diverse scientific backgrounds as a thioredoxin binding protein that negatively regulates the expression and the activity of thioredoxin, and is thus involved in redox regulation. Further studies have revealed that VDUP1 plays multiple roles in a wide range of cellular processes such as proliferation or apoptosis. Recently, it has been reported that VDUP1 is also involved in the immune system via positive regulation of natural killer development. In addition, VDUP1 has been revealed to be associated with the fatty acid utilization. In the present review, we discuss the novel aspects of VDUP1 function as well as the historical background of VDUP1. Future studies will explore the diagnostic and therapeutic potential of modulating the function of VDUP1 in vivo.
机译：维生素D（3）上调蛋白1（VDUP1）是一种46 kDa的多功能蛋白，最初在HL-60细胞中分离为通过维生素D（3）给药上调表达的蛋白。随后，它被来自不同科学背景的研究者独立地鉴定为硫氧还蛋白结合蛋白，它负调控硫氧还蛋白的表达和活性，并因此参与了氧化还原调节。进一步的研究表明，VDUP1在广泛的细胞过程中（例如增殖或凋亡）起着多种作用。最近，据报道，VDUP1也通过对自然杀手发育的积极调节而参与免疫系统。此外，已发现VDUP1与脂肪酸利用有关。在本文中，我们讨论了VDUP1功能的新颖方面以及VDUP1的历史背景。未来的研究将探索在体内调节VDUP1功能的诊断和治疗潜力。

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