...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of dermatology >Pilomatrix carcinoma arising from pilomatricoma after 10-year senescent period: Immunohistochemical analysis.
【24h】

Pilomatrix carcinoma arising from pilomatricoma after 10-year senescent period: Immunohistochemical analysis.

机译：十年的衰老期后由毛发瘤引起的毛发瘤：免疫组织化学分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pilomatrix carcinoma is a rare malignant counterpart of pilomatricoma. To our knowledge, only approximately 90 cases have been published in English literature. Pilomatrix carcinoma is locally aggressive and occasionally shows rapid progression infiltrating to the muscle, bone and vessels. We report a case of pilomatrix carcinoma that developed in a 38-year-old man and started to grow after a long stable period, relapsed for a short time and infiltrated into the muscle underneath. While the initial skin biopsy showed histopathological findings consistent with pilomatricoma, the recurrent tumor contained marked cellular atypia and an aggressive growth pattern. Although it is still controversial whether pilomatrix carcinoma arises de novo or through malignant transformation of a pilomatricoma, the present case might be caused by the latter process considering the patient's clinical course. beta-catenin is a downstream effecter in the canonical pathway of Wnt, acting as a signal for cell differentiation and proliferation. The characteristic nuclear staining pattern of beta-catenin in the basaloid tumor cells, which is usually observed in pilomatrix carcinoma, supported the diagnosis of pilomatrix carcinoma in the present case.
机译：pilomatrix癌是pilomatricoma的罕见恶性对应物。据我们所知，英语文献中仅发表了约90例。幽门螺杆菌是局部侵袭性的，偶尔显示浸润到肌肉，骨骼和血管的快速进展。我们报告了一个在38岁的男性中发生并在长期稳定期后开始生长，在短时间内复发并浸入下面的肌肉中开始生长的pilomatrix癌的病例。最初的皮肤活检显示与绒毛瘤一致的组织病理学发现，但复发的肿瘤包含明显的细胞异型性和侵袭性生长模式。尽管是从头发生还是通过毛发恶性转化恶性转化而引起的皮瘤组织癌仍存在争议，但考虑到患者的临床病程，本病例可能是由后者引起的。 β-catenin是Wnt常规途径中的下游效应物，可作为细胞分化和增殖的信号。 β-catenin在基底肿瘤细胞中的特征性核染色模式（通常在pilomatrix癌中观察到）支持了本例中的pilomatrix癌的诊断。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号