• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >The relationship between antipsychotic treatment and quality of life for patients with dementia living in residential and nursing home care facilities.
【24h】

The relationship between antipsychotic treatment and quality of life for patients with dementia living in residential and nursing home care facilities.

机译：生活在住宅和养老院中的痴呆患者的抗精神病药物治疗与生活质量之间的关系。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

For any treatment, the impact on quality of life (QoL) is a key consideration. These issues are particularly important in the pharmacologic management of behavioral and psychological symptoms in patients with dementia (BPSD). Although these symptoms can be very distressing for some patients, the overall relationship of the symptoms with QoL is far less clear. In addition, although antipsychotic agents have moderate efficacy in the short- to medium-term management of these symptoms, it cannot be assumed that symptom resolution automatically equates with improved QoL. This is of particular concern in light of the adverse side effect profiles of many of these agents. Indeed, the only empirical study in this area conducted to date indicated that antipsychotics are associated with a worse QoL for nursing home patients. Unfortunately, none of the placebo-controlled trials of antipsychotics for the treatment of BPSD have included formal QoL measures, although preliminary evidence indicates that atypical antipsychotics such as quetiapine may result in QoL improvements. The inclusion of systematic QoL measures in future clinical trials is imperative in order to provide evidence to enable the clinician to make informed judgments regarding the potential benefits or risks of pharmacologic treatment for individual patients. In addition, such information will facilitate a better understanding of the likely factors that may contribute to the impact of treatment on QoL (e.g., side effects) and hence enable physicians to make rational treatment choices between different pharmacologic agents.
机译：对于任何治疗，对生活质量（QoL）的影响都是关键考虑因素。这些问题在痴呆症患者的行为和心理症状的药理管理中尤为重要。尽管这些症状可能使某些患者感到非常痛苦，但这些症状与QoL的总体关​​系还远远不清楚。此外，尽管抗精神病药在这些症状的中短期治疗中具有中等疗效，但不能认为症状缓解自动等同于改善的QoL。鉴于许多这些药剂的不良副作用，这是特别令人关注的。确实，迄今为止在该领域进行的唯一一项经验研究表明，抗精神病药与疗养院患者的生活质量较差有关。不幸的是，尽管有初步证据表明非典型的抗精神病药物如喹硫平可导致QoL改善，但安慰剂对照的抗精神病药物治疗BPSD的试验均未包括正式的QoL措施。当务之急是在未来的临床试验中纳入系统的QoL措施，以提供证据，使临床医生能够就药物治疗对个别患者的潜在益处或风险做出明智的判断。另外，这些信息将有助于更好地理解可能对治疗对QoL产生影响的可能因素（例如副作用），从而使医生能够在不同的药物之间做出合理的治疗选择。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号