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首页> 外文期刊>The Journal of dermatology >Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.
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Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.

机译：牛皮癣患者中，由于维生素D3软膏（1,24（OH）2D3）与噻嗪类利尿剂合用而引起的医源性高钙血症。

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摘要

Tacalcitol is a synthetic vitamin D3 analogue developed for topical treatment of inflammatory skin diseases such as psoriasis. Hypercalcemia has not been previously reported during treatment with topical tacalcitol. We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia. After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually. On day 28 of the treatment, his serum calcium levels had reached 3.55 mmol/l, and his urinary calcium excretion had also increased from 0.008 g/day to 0.475 g/day. The tacalcitol treatment was terminated, seven days later, the serum calcium level had returned to the reference range without any specific treatment. The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.
机译：Tacalcitol是合成的维生素D3类似物，用于局部治疗炎症性皮肤病（如牛皮癣）。以前未曾报道用他克他糖醇进行局部治疗期间的高钙血症。我们经历了一名男性牛皮癣和高血压患者，他们分别用他骨化醇软膏和噻嗪类药物治疗，导致高钙尿症和高钙血症。皮肤损伤开始使用局部维生素D3软膏（20克/克他骨化醇）10克/天后，血清钙水平和尿钙排泄量逐渐增加。在治疗的第28天，他的血清钙水平达到3.55 mmol / l，他的尿钙排泄也从0.008 g /天增加到0.475 g /天。 tacalcitol治疗终止，七天后，血清钙水平未经过任何特殊处理即恢复到参考范围。本例是维生素D3软膏和噻嗪同时引起的高钙血症的首次报道。

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