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首页> 外文期刊>The Journal of dermatology >Churg-Strauss syndrome (CSS) manifested as necrosis of fingers and toes and liver infarction.
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Churg-Strauss syndrome (CSS) manifested as necrosis of fingers and toes and liver infarction.

机译：Churg-Strauss综合征（CSS）表现为手指和脚趾坏死和肝梗塞。

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We report a case of Churg-Strauss syndrome (CSS) with necrosis of the fingers and toes and liver infarction. A 59-year-old man with asthma suddenly noticed that his fingers and toes felt unusually cold. This condition worsened progressively, and some digits became necrotic within several weeks. Laboratory studies revealed hypereosinophilia and an extremely elevated serum level of IgE. Digital subtraction angiography of the extremities revealed extensive irregular narrowing of small and medium-sized arteries in the extremities. Abdominal computed tomography (CT) revealed an area of low density at the periphery of the right lobe of the liver. Angiography revealed irregular narrowing of small arteries that corresponded to the ischemic area. A nerve conduction study suggested sensory nerve neuropathy. The preceding asthma, acute onset of digital necrosis, liver infarction, neuropathy, and hypereosinophilia strongly suggested a diagnosis of CSS. The patient was treated with 40 mg of prednisolone and 120 micro g of intravenous prostaglandin E1 daily, and all the digits that had turned black and necrotic were amputated. After the amputation, the dose of prednisolone was gradually reduced, and no new lesions appeared on the skin or in the liver. The rare possible complications of CSS, including necrosis of digits and liver infarction, should not be ignored.
机译：我们报告一例Churg-Strauss综合征（CSS）的手指和脚趾坏死和肝梗死。一名59岁的哮喘男子突然发现他的手指和脚趾感到异常寒冷。这种情况逐渐恶化，几周内一些数字坏死。实验室研究发现嗜酸性粒细胞增多和血清IgE水平极高。四肢的数字减影血管造影显示四肢中的中小动脉广泛不规则变窄。腹部计算机断层扫描（CT）显示肝脏右叶周围区域的低密度区域。血管造影显示对应于缺血区域的小动脉不规则变窄。神经传导研究提示感觉神经神经病变。先前的哮喘，数字坏死的急性发作，肝梗塞，神经病和嗜酸性粒细胞增多强烈提示诊断为CSS。该患者每天接受40 mg泼尼松龙和120 micro g静脉注射前列腺素E1的治疗，将所有变黑和坏死的手指切断。截肢后，泼尼松龙的剂量逐渐减少，皮肤或肝脏中没有新的病变出现。 CSS罕见的可能并发症，包括手指坏死和肝梗塞，不容忽视。

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