...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of dermatology >Pemphigus in Korea: clinical manifestations and treatment protocol.
【24h】

Pemphigus in Korea: clinical manifestations and treatment protocol.

机译：韩国的天疱疮：临床表现和治疗方案。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pemphigus, a rare, chronic blistering disease of the skin and mucous membranes with severe morbidity and occasional mortality, is the most common autoimmune bullous disease in Korea. The purpose of this study was to evaluate the clinical features and propose a treatment strategy for patients with pemphigus. A retrospective analysis was conducted of 51 pemphigus patients seen between 1993 and 2001. Pemphigus vulgaris (PV) was the most common type with 32 cases, followed by 19 cases of pemphigus foliaceus (PF). The male to female ratio was 1:1.3, with females predominating, particularly among PV patients (PV, 1:1.5; PF, 1:1.1). The average ages at onset of PV and PF were 44.3 and 51.0 years old, respectively. Mucosal involvement was noted in 27 cases (84.4%) of PV but in only 3 cases (15.8%) of PF. Most patients initially received relatively low to intermediate doses (0.3-1.0 mg/kg/day) of prednisolone, and 23 (71.9%) PV patients and 10 (52.6%) PF patients also received immunosuppressive agents. Oral prednisolone and azathioprine (100 mg/day) formed the mainstay of treatment for our patients (47.1%). At the time of writing, 25.5% (13/51) of patients are in complete remission, and 72.5% (37/51) are undergoing maintenance therapy. One patient died due to sepsis during the treatment. For the treatment of pemphigus, a course of the lowest possible corticosteroid dosage in combination with immunosuppressive agents appears to be effective and less toxic than a high corticosteroid dosage.
机译：天疱疮是一种罕见的慢性皮肤和粘膜水疱病，发病率高，偶有死亡，是韩国最常见的自身免疫性大疱性疾病。这项研究的目的是评估天疱疮的临床特征并提出治疗策略。回顾性分析了1993年至2001年间的51名天疱疮患者。寻常型天疱疮（PV）是32例，其次是叶天疱疮（PF）19例。男女比例为1：1.3，其中女性占主导地位，特别是在PV患者中（PV，1：1.5; PF，1：1.1）。 PV和PF的平均发病年龄分别为44.3岁和51.0岁。粘膜受累在PV的27例（84.4％）中，但仅PF的3例（15.8％）。最初，大多数患者接受泼尼松龙的中低剂量（0.3-1.0 mg / kg /天），并且23例（71.9％）PV患者和10例（52.6％）PF患者也接受了免疫抑制剂。口服泼尼松龙和硫唑嘌呤（100毫克/天）构成了我们患者的主要治疗手段（47.1％）。在撰写本文时，25.5％（13/51）的患者已完全缓解，而72.5％（37/51）的患者正在接受维持治疗。一名患者在治疗期间因败血症死亡。对于天疱疮的治疗，与高剂量的皮质类固醇激素剂量相结合，一疗程中尽可能低的皮质类固醇激素剂量与免疫抑制剂合用似乎是有效的且毒性较小。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号