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首页> 外文期刊>The Journal of dermatology >Case of co-morbidity of alopecia areata and pityriasis lichenoides in a five year old boy for two years.
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Case of co-morbidity of alopecia areata and pityriasis lichenoides in a five year old boy for two years.

机译：五岁男孩两年内发生斑秃和糠疹性糠疹的合并症。

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A 5-year-old Indo-Taiwanese mixed boy was brought to us with concurrence of multifocal alopecia areata (AA) and pityriasis lichenoides (PL) of 1 year. On examination, there were several circumscribed bald patches over his scalp without erythematous or scaly changes (Fig. 1). Additionally, 20-30 papulonecrotic lesions were scattered mainly over the trunk and proximal extremities (Fig. 2a), and showed typical features of PL characterized histopathologically by a superficial and deep dermal lymphohistiocytic infiltrate, confluent parakeratosis, vacuolar change at the dermoepidermal junction, ballooning of keratinocytes with intraepidermal vesiculation and necrosis of keratinocytes (Fig. 2b). According to his mother, he first became ill with malaise, sore throat, arthralgia and fever of up to 39癈 during travel in India, followed by the first attack of cutaneous lichenoid papules in 2 weeks. Soon thereafter, several foci of alopecia areata developed with involvement of eyebrows and trunk. Family history ofatopicdiathesis with allergic rhinitis was identified in the boy and his mother. Virology study showed negative findings of infection with Epstein-Barr virus (EB-VCA immunoglobulin [lg]A, EB-VCA IgG, EB-VCA IgM, EBEA, EBNA), cytomegalovirus (CMV IgG, CMV IgM) and Toxoplasma gondii (T. gondii IgG, T. gondii IgM). Treatment with systemic antibiotics and corticoster-oids was attempted without significant modification of the disease course. In the ensuing 2-year follow up, the two kinds of skin lesions seemed to wax and wane in parallel, with PL usually preceding the activity of AA.
机译：一个5岁的印度-台湾混血男孩被带到我们身边，同时患有多灶性斑秃（AA）和糠疹性糠疹（PL）1年。检查时，在他的头皮上有几个外接的秃头斑块，没有红斑或鳞屑变化（图1）。此外，20-30个丘疹坏死性病变主要散布在躯干和近端（图2a），并显示了PL的典型特征，其组织病理学特征为浅表和深层真皮淋巴组织细胞浸润，融合性角化不全，真皮表皮交界处的液泡改变，膨胀表皮内囊泡化和角质形成细胞坏死的结果（图2b）。据他的母亲说，在印度旅行期间，他首先因不适，喉咙痛，关节痛和发烧而生病，发烧高达39度，然后在2周内首次发作皮肤苔藓样丘疹。此后不久，出现了数个斑秃灶，并伴有眉毛和躯干。在男孩和他的母亲中发现了过敏性鼻炎的特应性素质家族史。病毒学研究显示，感染了爱泼斯坦-巴尔病毒（EB-VCA免疫球蛋白[lg] A，EB-VCA IgG，EB-VCA IgM，EBEA，EBNA），巨细胞病毒（CMV IgG，CMV IgM）和弓形虫（T弓形虫IgG，弓形虫IgM）。尝试使用全身性抗生素和皮质类固醇激素治疗，而没有明显改变病程。在随后的2年随访中，两种皮肤病变似乎同时起蜡和消退，PL通常先于AA活动。

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