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首页> 外文期刊>The Journal of dermatology >Single-dose oral fluconazole versus topical clotrimazole in patients with pityriasis versicolor: A double-blind randomized controlled trial.
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Single-dose oral fluconazole versus topical clotrimazole in patients with pityriasis versicolor: A double-blind randomized controlled trial.

机译：杂色性糠疹患者单剂量口服氟康唑与局部克霉唑的比较：一项双盲随机对照试验。

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摘要

This study was designed to compare the therapeutic effects of topical clotrimazole and systemic fluconazole in pityriasis versicolor. A double-blind randomized controlled trial was carried out in the dermatological clinic of Gorgan, northern Iran, between April 2006 and May 2007. All consecutive patients with pityriasis versicolor were included and randomly divided into two groups. In the first group (G1), patients underwent treatment with a single dose of fluconazole capsule (400 mg) and placebo cream. In the second group (G2), patients underwent treatment with clotrimazole cream (twice daily) and placebo capsule. The course of treatment was 2 weeks. All subjects were re-evaluated 2, 4 and 12 weeks after the end of the therapeutic course. After 2 weeks, the rate of complete resolution of disease was significantly higher in G2 than G1 (49.1% vs 30%). After 4 weeks, 41 patients (81.2%) of G1 and 52 patients (94.9%) of G2 showed complete resolution. After 12 weeks, 46 patients (92%) in G1 and 45 patients (81.8%) in G2 showed complete resolution. Recurrence rate in G1 and G2 were 6% and 18.2%, respectively. No complications were seen in either group. In this study, clinical response at week 4 was greater in the clotrimazole group than the fluconazole group. Recurrence at week 12 after treatment was less with oral fluconazole than clotrimazole cream. So, for better evaluation, more studies need to be done.
机译：本研究旨在比较局部用克霉唑和全身性氟康唑对云芝糠疹的治疗效果。在2006年4月至2007年5月间，在伊朗北部Gorgan的皮肤病诊所进行了一项双盲随机对照试验。纳入了所有连续的杂色牛皮癣患者，并随机分为两组。在第一组（G1）中，患者接受单剂量氟康唑胶囊（400 mg）和安慰剂乳膏治疗。在第二组（G2）中，患者接受克霉唑乳膏（每日两次）和安慰剂胶囊治疗。治疗过程为2周。治疗疗程结束后第2、4和12周对所有受试者进行了重新评估。 2周后，G2中疾病的完全解决率显着高于G1（49.1％对30％）。 4周后，G1的41例患者（81.2％）和G2的52例患者（94.9％）显示完全消退。 12周后，G1组46例（92％）和G2组45例（81.8％）表现出完全的消退。 G1和G2的复发率分别为6％和18.2％。两组均未见并发症。在这项研究中，克霉唑组第4周的临床反应大于氟康唑组。口服氟康唑治疗后第12周的复发率低于克霉唑乳膏。因此，为了获得更好的评估，需要做更多的研究。

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