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首页> 外文期刊>The Journal of dermatology >Antimicrobial peptides in the pathogenesis of psoriasis
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Antimicrobial peptides in the pathogenesis of psoriasis

机译：牛皮癣发病机理中的抗菌肽

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摘要

One characteristic abnormality of lesional skin in psoriasis is the excessive production of antimicrobial peptides and proteins (AMPs). AMPs typically are small (12-50 amino acids), have positive charge and amphipathic structure, and are found in all living organisms including mammals, insects, plants and invertebrates. These peptides are best known for their integral role in killing pathogenic microorganisms; however, in vertebrates, they are also capable of modifying host inflammatory responses by a variety of mechanisms. In psoriatic lesions, many AMPs are highly expressed, and especially the associations between psoriasis and cathelicidin, β-defensins or S100 proteins have been well studied. Among them, a cathelicidin peptide, LL-37, has been highlighted as a modulator of psoriasis development in recent years. AMPs had been thought to worsen psoriatic lesions but recent evidence has also suggested the possibility that the induction of AMPs expression might improve aspects of the disease. Further investigations are needed to uncover a previously underappreciated role for AMPs in modulating the immune response in psoriasis, and to improve disease without the risks of systemic immunosuppressive approaches.
机译：银屑病皮损皮肤的特征性异常之一是抗菌肽和蛋白质（AMP）的过量产生。 AMPs通常很小（12-50个氨基酸），具有正电荷和两亲性结构，存在于所有活生物体中，包括哺乳动物，昆虫，植物和无脊椎动物。这些肽在杀死病原微生物中起着不可或缺的作用。然而，在脊椎动物中，它们也能够通过多种机制改变宿主的炎症反应。在牛皮癣病变中，许多AMPs都高度表达，尤其是牛皮癣和cathelicidin，β-defensins或S100蛋白之间的关联已得到很好的研究。其中，近年来，cathelicidin肽LL-37成为牛皮癣发展的调节剂。 AMP被认为会使牛皮癣的病情恶化，但是最近的证据也表明，诱导AMPs表达可能改善疾病的可能性。需要进一步的研究以发现以前在AMPs调节牛皮癣免疫反应中被低估的作用，并改善疾病而无全身免疫抑制方法的风险。

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