...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of dermatology >Monotherapy for vitiligo using a 308-nm xenon-chloride excimer laser. CoSorimetric assessment of factors that influence treatment efficacy
【24h】

Monotherapy for vitiligo using a 308-nm xenon-chloride excimer laser. CoSorimetric assessment of factors that influence treatment efficacy

机译：使用308 nm氯化氙氙准分子激光对白癜风进行单一疗法。影响治疗功效的因素的协计量评估

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The excimer laser selectively treats a small area without unnecessarily exposing normal skin to radiation. Several studies have confirmed the efficacy of excimer laser monotherapy or combination therapy for vitiligo, but their efficacy for recalcitrant vitiligo is unclear. The excimer laser is a more potent inducer of T-cell apoptosis than narrowband (NB) ultraviolet (UV)-B, and many cytokines are associated with melanocyte migration and DNA synthesis stimulation in melanocytes. We previously reported that endothelin-1, an intrinsic melanogen or mitogen for human melanocytes in UV-B-induced pigmentation, is induced more prominently by excimer laser than other UV-B light sources. In the present study, we evaluated the efficacy of 308-nm excimer laser monotherapy in 45 patients with 157 vitiligo lesions for up to 50 treatment sessions, which is a greater number of treatments than that given in previous studies. In addition, we assessed the minimal erythema dose (MED) and skin color and determined the factors that contribute to a positive response to excimer laser treatment.
机译：准分子激光器选择性地治疗小区域，而不会使正常皮肤不必要地受到辐射。几项研究已证实准分子激光单一疗法或联合疗法对白癜风的疗效，但对于顽固性白癜风的疗效尚不清楚。准分子激光比窄带（NB）紫外线（UV）-B更有效地诱导T细胞凋亡，并且许多细胞因子与黑素细胞的迁移和DNA合成刺激有关。我们先前曾报道内皮素-1，一种受激准分子激光比其他UV-B光源更显着地诱导内皮素-1，它是紫外线-B诱导的色素沉着中人黑色素细胞的固有黑色素或促细胞分裂剂。在本研究中，我们评估了308 nm准分子激光单一疗法在45个157个白癜风患者中的疗效，持续了多达50个疗程，这比以前的研究数量多。此外，我们评估了最小的红斑剂量（MED）和肤色，并确定了对准分子激光治疗产生积极反应的因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号