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首页> 外文期刊>The Journal of dermatology >Two Japanese cases of dermatitis herpetiformis associated each with lung cancer and autoimmune pancreatitis but showing no intestinal symptom or circulating immunoglobulin A antibodies to any known antigens
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Two Japanese cases of dermatitis herpetiformis associated each with lung cancer and autoimmune pancreatitis but showing no intestinal symptom or circulating immunoglobulin A antibodies to any known antigens

机译：日本有2例疱疹样皮炎病例，每例都与肺癌和自身免疫性胰腺炎有关，但没有肠症状或针对任何已知抗原的循环免疫球蛋白A抗体

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摘要

Dermatitis herpetiformis (DH) is common in some Caucasian populations but extremely rare in Japanese, probably because of different immunogenetic backgrounds. We report two Japanese DH cases with typical clinical, histological and direct immunofluorescence features. However, no symptom of gluten-sensitive enteropathy was shown. The diagnosis was confirmed by eliminating other autoimmune blistering diseases by indirect immunofluorescence, enzyme-linked immunosorbent assays and immunoblotting. However, circulating immurioglobulin (lg)A anti-endomysium, reticulin and gliadin antibodies were not detected. IgA antibodies to tissue and epidermal transglutaminases were also negative. One case was associated with lung cancer and the other one with autoimmune pancreatitis. On review of 17 cases of DH reported in Japan over the previous 10 years, including our cases, one case was associated with gluten-sensitive enteropathy, four with malignant neoplasms, two with autoimmune systemic disorders and one with psoriasis. Although our cases were typical of DH in clinical, histopatho-logical and IgA deposit features, they showed different human leukocyte antigen haplotypes, no gluten-sensitive enteropathy and no DH-specific IgA antibodies, including those to epidermal and tissue transglutaminases. These results suggest that studies of unique characteristics in Japanese DH patients should facilitate further understanding of pathogenesis in DH.
机译：疱疹性皮肤病（DH）在某些高加索人群中很常见，但在日本人中极为罕见，这可能是由于不同的免疫遗传背景。我们报告了两个典型的临床，组织学和直接免疫荧光特征的日本DH病例。然而，没有显示出对麸质敏感的肠病的症状。通过间接免疫荧光，酶联免疫吸附测定和免疫印迹消除了其他自身免疫性水疱性疾病，从而确认了诊断。但是，未检测到循环中的免疫球蛋白（lg）A抗内膜球菌，网状蛋白和麦醇溶蛋白抗体。针对组织和表皮转谷氨酰胺酶的IgA抗体也呈阴性。一例与肺癌有关，另一例与自身免疫性胰腺炎有关。在回顾了过去十年中日本报道的17例DH病例（包括我们的病例）后，其中1例与麸质敏感型肠病有关，4例与恶性肿瘤有关，2例与自身免疫性系统疾病有关，1例与牛皮癣有关。尽管我们的病例在临床，组织病理学和IgA沉积特征方面都是典型的DH，但它们显示出不同的人类白细胞抗原单倍型，没有面筋敏感的肠病，也没有DH特异性IgA抗体，包括针对表皮和组织转谷氨酰胺酶的IgA抗体。这些结果表明，对日本DH患者独特特征的研究应有助于进一步了解DH的发病机理。

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