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首页> 外文期刊>The Journal of dermatology >Successful treatment of oral itraconazole for infantile hemangiomas: A case series
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Successful treatment of oral itraconazole for infantile hemangiomas: A case series

机译：口服伊曲康唑成功治疗婴儿血管瘤的案例分析

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摘要

Infantile hemangiomas can present a therapeutic challenge to clinicians, especially when associated with severe pain and feeding difficulties. The standard therapeutic management includes corticosteroids and propranolol. However, the clinical response is not always satisfactory. We present six cases of infantile hemangiomas successfully treated with oral itraconazole approximately 5mg/kg per day. In the first month, the red color of the lesions became a little lighter and the growth of the lesions was controlled in all cases. An obvious clinical improvement was noted in all cases during the 3-month period, with 80-100% improvement in each patient at the end of the treatment, which was judged by both their parents and the dermatologists. Compliance with treatment instructions of oral itraconazole in infants was judged to be very good. Side-effects were mild and limited. Although itraconazole can inhibit angiogenesis and tumor growth in vitro and in vivo associated with some cancers, further research is required to understand the pathogenesis of infantile hemangiomas and the mechanism of itraconazole.
机译：小儿血管瘤可对临床医生提出治疗挑战，尤其是在伴有严重疼痛和进食困难的情况下。标准治疗方法包括皮质类固醇和普萘洛尔。但是，临床反应并不总是令人满意的。我们目前有6例婴儿口服血管内伊曲康唑每天约5mg / kg成功治疗血管瘤。在第一个月中，病变的红色逐渐变浅，并且在所有情况下都控制了病变的生长。在三个月的时间里，所有病例均出现了明显的临床改善，在治疗结束时每位患者的改善率达到80-100％，这由其父母和皮肤科医生共同判断。婴儿口服伊曲康唑的治疗说明依从性良好。副作用轻微且有限。尽管伊曲康唑可以在体外和体内抑制某些癌症引起的血管生成和肿瘤生长，但仍需要进一步的研究来了解婴儿血管瘤的发病机理和伊曲康唑的作用机理。

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