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首页> 外文期刊>The Journal of dermatology >Hair shaft miRNA-221 levels as a new tumor marker of malignant melanoma
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Hair shaft miRNA-221 levels as a new tumor marker of malignant melanoma

机译：发干miRNA-221水平作为恶性黑色素瘤的新肿瘤标志物

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摘要

miRNA-221 (miR-221) is known to be abnormally expressed in many human cancers. The serum levels of miR-221 have been reported as a tumor marker for malignant melanoma (MM). We hypothesized that the hair shaft miR-221 levels may be increased in patients with MM. We therefore assessed the possibility that hair shaft miR-221 levels could be a marker for MM. The hair shaft miR-221 levels were significantly higher in patients with MM than controls. The rates of increased hair shaft miR-221 levels above the cut-off value were comparable to those of serum 5-S-CD, which is a tumor marker commonly used for MM. Measurements of the hair shaft miR-221 levels could have potential clinical value in the detection of MM. This is the first report investigating the hair shaft levels of an miRNA in patients with MM. Our investigations offer new insight into the relationship between miR-221 and MM, and may provide a new, non-invasive way to screen for melanoma.
机译：已知miRNA-221（miR-221）在许多人类癌症中均异常表达。据报道，miR-221的血清水平是恶性黑色素瘤（MM）的肿瘤标志物。我们假设MM患者的毛干miR-221水平可能升高。因此，我们评估了发干miR-221水平可能是MM标志的可能性。 MM患者的发干miR-221水平显着高于对照组。高于临界值的发干miR-221水平升高的速率与血清5-S-CD相当，后者是MM常用的肿瘤标志物。毛干miR-221水平的测量在检测MM中可能具有潜在的临床价值。这是第一份研究MM患者miRNA发干水平的报告。我们的研究为miR-221和MM之间的关系提供了新的见解，并可能提供一种新的，非侵入性的黑色素瘤筛查方法。

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