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首页> 外文期刊>The Journal of dermatology >Histopathological diagnosis of epithelial crateriform tumors: Keratoacanthoma and other epithelial crateriform tumors
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Histopathological diagnosis of epithelial crateriform tumors: Keratoacanthoma and other epithelial crateriform tumors

机译：上皮纹状体肿瘤的组织病理学诊断：角棘皮瘤和其他上皮纹状体肿瘤

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Keratoacanthoma (KA) is a unique and distinct clinicopathological entity, although there is often confusion regarding its differentiation from other types of crateriform tumors. In this study, the clinicopathological features of 380 epidermal crateriform tumors with a central keratin plug were re-examined and the tumors were histologically classified into seven types: (i) crateriform verruca; (ii) crateriform seborrheic keratosis; (iii) KA; (iv) KA with a conventional squamous cell carcinoma (SCC) component (KA-like SCC and KA with malignant transformation); (v) crateriform Bowen's disease; (vi) crateriform SCC arising from solar keratosis; and (vii) crater form of infundibular SCC. Our study proved that incidence of SCC developing in KA lesions was 17.4%. The incidence rate differed depending on a patient's ages: 8.3% in patients less than 70 years of age and 24.3% in those aged 70 years and older. Nearly all of the malignant crateriform neoplasms (94.7%) occurred on sun-exposed areas. Lesions on the face included 138 KA (59.5%), 65 malignant crateriform neoplasms (28%) and 29 benign crateriform neoplasms (12.5%). We conclude that KA is not a variant of SCC, but a benign and frequently regressing proliferative lesion or borderline neoplasm, although there is the potential for SCC to arise within KA. Because the incidence of SCC developed in KA lesions and the incidence of other malignant crateriform neoplasms are higher in patients aged 70 years and older, KA-like lesions on sun-exposed areas over 70 should be assessed carefully in consideration of the potential risk of malignancy.
机译：角棘皮瘤（KA）是一种独特而独特的临床病理学实体，尽管其与其他类型的颅状肿瘤的区别常常令人困惑。在这项研究中，对380具中央角蛋白塞的表皮角状肿瘤的临床病理特征进行了重新检查，并将肿瘤在组织学上分为七种类型：（i）角状疣。 （ii）火山口状脂溢性角化病; （iii）KA; （iv）具有常规鳞状细胞癌（SCC）成分的KA（KA样SCC和具有恶性转化的KA）; （v）克拉状鲍文氏病; （vi）由日光性角化病引起的角状SCC; （vii）漏斗状SCC的火山口形式。我们的研究证明，KA病变中发生SCC的发生率为17.4％。发病率因患者年龄而异：70岁以下患者为8.3％，70岁以上患者为24.3％。几乎所有恶性火山口状肿瘤（94.7％）都发生在受阳光照射的区域。面部病变包括138 KA（59.5％），65个恶性角状肿瘤（28％）和29个良性角状肿瘤（12.5％）。我们得出结论，尽管KA中可能存在SCC，但KA不是SCC的变体，而是良性且经常消退的增生性病变或边缘性肿瘤。由于KA病变中发生SCC的发生率以及70岁及以上的患者中其他恶性陨石状肿瘤的发生率更高，因此应仔细评估70岁以上受太阳照射的地区的KA样病变，以考虑潜在的恶性风险。

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