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首页> 外文期刊>The Journal of dermatology >Potential preventive effects of proactive therapy on sensitization in moderate to severe childhood atopic dermatitis: A randomized, investigator-blinded, controlled study
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Potential preventive effects of proactive therapy on sensitization in moderate to severe childhood atopic dermatitis: A randomized, investigator-blinded, controlled study

机译：前瞻性治疗对中度至重度儿童特应性皮炎致敏作用的潜在预防作用：一项随机，研究者盲对照研究

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Proactive therapy for atopic dermatitis (AD) effectively prevents exacerbation. However, its role in preventing subsequent sensitization to allergens has not been prospectively studied. We investigated whether proactive therapy for AD can effectively impact immunological parameters in a randomized, investigator-blinded, parallel group study. Thirty patients aged 3 months to 7 years with moderate to severe AD who had undergone an AD educational program were allocated to a proactive treatment group or a reactive treatment group. During the disease control period, patients in the proactive group performed intermittent preventive application of topical corticosteroid for 1 year. Changes in the severity scoring, quality of life measures and immunological parameters (serum thymus and activation regulated chemokine [TARC], total immunoglobulin E [IgE] and house dust mite-specific IgE levels) were evaluated and compared between the proactive and reactive treatment groups. Although the average topical corticosteroid ointment use per day in both groups was not significantly different, the severity and quality of life scores were significantly lower in the proactive group than in the reactive group at the final visit. In addition, compared with baseline levels, serum TARC levels remained significantly lower during proactive therapy, while house dust mite-specific IgE levels were significantly increased only in the reactive group. The results suggest that in addition to controlling the severity of AD, intermittent preventive administration of topical corticosteroids may prevent an increase in aeroallergen-specific IgE levels in patients with childhood AD. The use of TARC levels as a biomarker for AD remission is also supported.
机译：积极治疗特应性皮炎（AD）可有效防止病情加重。但是，其在防止随后对过敏原致敏中的作用尚未进行前瞻性研究。我们在一项随机，研究者盲目的平行小组研究中调查了针对AD的积极治疗是否能有效影响免疫学参数。将接受过AD教育计划的30例3个月至7岁的中度至重度AD患者分为主动治疗组或被动治疗组。在疾病控制期间，积极组的患者进行了局部皮质类固醇激素的间歇性预防应用1年。评估积极治疗组和反应治疗组之间的严重程度评分，生活质量测量和免疫学参数（血清胸腺和活化调节趋化因子[TARC]，总免疫球蛋白E [IgE]和屋尘螨特定IgE水平）的变化，并进行比较。尽管两组的平均每日局部外用皮质类固醇软膏使用量无显着差异，但在最后一次就诊时，积极组的反应的严重程度和生活质量得分显着低于反应组。此外，与基线水平相比，在积极治疗期间血清TARC水平仍然显着降低，而屋尘螨特异性IgE水平仅在反应组中显着增加。结果表明，除了控制AD的严重程度外，局部预防性给予局部皮质类固醇激素可能还可以防止儿童AD患者的气敏原特异性IgE水平升高。还支持将TARC含量用作AD缓解的生物标志物。

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