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首页> 外文期刊>The Journal of dermatology >Serum levels of soluble programmed death-1 and programmed death ligand-1 in systemic sclerosis: Association with extent of skin sclerosis
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Serum levels of soluble programmed death-1 and programmed death ligand-1 in systemic sclerosis: Association with extent of skin sclerosis

机译：全身性硬化症中可溶性程序性死亡1和程序性死亡配体1的血清水平：与皮肤硬化程度的关联

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The interaction of programmed death-1 (PD-1) with its ligand, programmed death ligand-1 (PD-L1), has been considered to play a key role in the negative regulation of immune responses. Patients with diffuse cutaneous systemic sclerosis (SSc) had higher levels of soluble PD-1 (sPD-1) than those with limited cutaneous SSc and healthy individuals. Serum sPD-1 levels positively correlated with the severity of skin sclerosis. In contrast, serum sPD-L1 levels were significantly increased in patients with SSc compared with healthy individuals. Moreover, serum sPD-L1 levels were not associated with the extent of skin sclerosis and were elevated not only in patients with diffuse cutaneous SSc, but also in those with limited cutaneous SSc. These results suggested that serum sPD-1 levels may increase in patients with SSc and correlate with the severity of skin sclerosis. PD-1/PD-L1 interaction may contribute to the development of skin sclerosis in SSc.
机译：程序性死亡-1（PD-1）与它的配体程序性死亡配体-1（PD-L1）的相互作用被认为在免疫反应的负调控中起关键作用。患有弥漫性皮肤系统性硬化症（SSc）的患者可溶性PD-1（sPD-1）的水平要高于那些皮肤SSc有限和健康个体的患者。血清sPD-1水平与皮肤硬化的严重程度呈正相关。相反，与健康个体相比，SSc患者的血清sPD-L1水平显着升高。此外，血清sPD-L1水平与皮肤硬化程度无关，不仅在皮肤弥漫性SSc患者中升高，而且在皮肤SSc有限的患者中也升高。这些结果表明SSc患者的血清sPD-1水平可能升高，并与皮肤硬化的严重程度相关。 PD-1 / PD-L1相互作用可能促进SSc中皮肤硬化的发展。

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