...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of dermatology >Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives
【24h】

Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives

机译：商业镇静剂引起的模仿皮肤坏疽性脓皮病的皮肤病

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Bromoderma is a rare skin disorder caused by bromide intake. It presents as single or multiple papillomatous nodules or plaques, and ulcers studded with small pustules on the face or limbs. The clinical features of bromoderma are similar to those of pyoderma gangrenosum. A 41-year-old Japanese woman was diagnosed with pyoderma gangrenosum 11years prior to presentation. Pyoderma had repeatedly appeared over her entire body despite treatment. She also frequently complained of syncopal episodes. She was admitted to our hospital after loss of consciousness and an episode of generalized convulsion. Laboratory tests revealed a negative serum anion gap and hyperchloremia. Her serum bromide level was significantly elevated, suggesting bromide intoxication. The patient had a 10-year history of high serum bromide levels. After the intake of bromide-containing sedatives was stopped, there was no recurrence of pyoderma in the absence of treatment. In conclusion, this case was diagnosed as bromoderma with commercial sedative-induced bromide intoxication. Although the US Food and Drug Administration have banned the use of bromides, over-the-counter (OTC) treatments containing bromides are still used in Japan and other countries. Long-term use of OTC medicines containing bromvalerylurea may result in the development of bromoderma. If unclarified neurological or psychiatric symptoms are associated with pyoderma, we propose measurement of the patient's serum chloride concentration. Determination of hyperchloremia is helpful for the diagnosis of chronic intoxication with bromides.
机译：溴皮病是由溴化物摄入引起的罕见皮肤病。它表现为单个或多个乳头状结节或斑块，溃疡表面或四肢散布着小脓疱。溴代皮肤病的临床特征类似于坏疽性脓皮病。出诊前11年，一名41岁的日本妇女被诊断患有坏疽性脓皮病。尽管接受了治疗，脓皮病却反复出现在她的整个身体上。她还经常抱怨晕厥发作。失去知觉和全身性抽搐发作后，她被送进我们医院。实验室检查发现血清阴离子间隙和高氯血症为阴性。她的血清溴化物水平显着升高，表明溴化物中毒。该患者有高血清溴化物水平10年的病史。停止摄入含溴化物的镇静剂后，在不进行治疗的情况下，脓皮病没有复发。总之，该病例被诊断为患有商业镇静剂诱导的溴化物中毒的溴化皮肤病。尽管美国食品药品监督管理局已禁止使用溴化物，但日本和其他国家/地区仍在使用含有溴化物的非处方（OTC）处理方法。长期使用含有溴戊脲的非处方药可能会导致皮肤病的发展。如果脓毒症伴有不清楚的神经或精神症状，我们建议测量患者的血清氯化物浓度。高氯血症的测定有助于诊断慢性溴中毒。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号