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首页> 外文期刊>The Journal of dermatology >Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness
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Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness

机译：嗜酸性脓疱性毛囊炎：已发表的基于工作的治疗反应综合分析

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摘要

Eosinophilic pustular folliculitis (EPF) is a non-infectious inflammatory dermatosis of unknown etiology that principally affects the hair follicles. There are three variants of EPF: (i) classic EPF; (ii) immunosuppression-associated EPF, which is subdivided into HIV-associated (IS/HIV) and non-HIV-associated (ISon-HIV); and (iii) infancy-associated EPF. Oral indomethacin is efficacious, especially for classic EPF. No comprehensive information on the efficacies of other medical management regimens is currently available. In this study, we surveyed regimens for EPF that were described in articles published between 1965 and 2013. In total, there were 1171 regimens; 874, 137, 45 and 115 of which were applied to classic, IS/HIV, ISon-HIV and infancy-associated EPF, respectively. Classic EPF was preferentially treated with oral indomethacin with efficacy of 84% whereas topical steroids were preferred for IS/HIV, ISon-HIV and infancy-associated EPF with efficacy of 47%, 73% and 82%, respectively. Other regimens such as oral Sairei-to (a Chinese-Japanese herbal medicine), diaminodiphenyl sulfone, cyclosporin and topical tacrolimus were effective for indomethacin-resistant cases. Although the preclusion of direct comparison among cases was one limitation, this study provides a dataset that is applicable to the construction of therapeutic algorithms for EPF.
机译：嗜酸性脓疱性毛囊炎（EPF）是一种病因不明的非感染性炎症性皮肤病，主要影响毛囊。 EPF有三种变体：（i）经典EPF; （ii）免疫抑制相关的EPF，可分为与HIV相关的（IS / HIV）和与非HIV相关的（IS / non-HIV）; （iii）婴儿相关的EPF。口服消炎痛是有效的，特别是对于经典的EPF。目前尚无关于其他医疗管理方案功效的全面信息。在这项研究中，我们调查了1965年至2013年之间发表的文章中描述的EPF方案。总共有1171方案;其中1方案被接受。其中874、137、45和115分别应用于经典，IS / HIV，IS /非HIV和婴儿期EPF。经典的EPF首选口服消炎痛治疗，疗效为84％，而局部类固醇对于IS / HIV，IS / non-HIV和与婴儿相关的EPF疗效较好，分别为47％，73％和82％。其他方案，如口服塞瑞妥（中日草药），二氨基二苯砜，环孢菌素和他克莫司局部用药对耐吲哚美辛的病例有效。尽管排除病例之间直接比较的局限性是一个局限性，但本研究提供了可用于构建EPF治疗算法的数据集。

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