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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Perinatal outcome for pregnancies complicated with thrombocytopenia
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Perinatal outcome for pregnancies complicated with thrombocytopenia

机译：妊娠合并血小板减少症的围产期结局

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Introduction: Thrombocytopenia affects about 10% of all pregnancies. Preeclampsia/HELLP syndrome induced thrombocytopenia may associate perinatal morbidity, preterm delivery, or low-birth-weight newborns. Objective: To assess perinatal outcome and complications of pregnancy in women presenting with thrombocytopenia. Methods: We retrospectively analyzed 936 consecutive pregnant women admitted during a 6-month period. Results: Incidence of thrombocytopenia in pregnancy was 11.11% (104/936). Thrombocytopenia represented a risk factor for premature delivery highest risk for severe thrombocytopenia (RR8.69, p<0.01). Thrombocytopenic preeclampsia or HELLP syndrome associated the highest rates of prematurity (RR7.97, p0.00, respectively 12.32). Thrombocytopenia also represented a risk factor for low-birth-weight newborns, especially severe thrombocytopenia 2047.50±938.98g (p0.02) versus 3224.86±496.00g in controls. Again, thrombocytopenic preeclampsia was significantly associated with low-birth-weight newborns (RR11.94, p0.00), with medium weight of 2462.05±794.54g versus 2932.37±708.91g in thrombocytopenic pregnancies, respectively 3224.86±496.00g (p0.00) in normal pregnancies. Conclusions: Thrombocytopenia in pregnancy was associated with perinatal morbidity, with the strongest association for preeclampsia and HELLP syndrome for both prematurity and low-birth-weight: the lower the platelet count, the higher the risks for the fetusewborn. Therefore, we strongly recommend close surveillance of thrombocytopenic mothers and their babies, in order to establish the etiology and the best moment for intervention.
机译：简介：血小板减少症影响所有怀孕的10％。子痫前期/ HELLP综合征诱发的血小板减少症可能与围产期发病，早产或低出生体重的新生儿有关。目的：评估血小板减少症妇女的围产期结局和妊娠并发症。方法：我们回顾性分析了6个月内收治的936名连续孕妇。结果：妊娠期间血小板减少症的发生率为11.11％（104/936）。血小板减少症是早产的危险因素，重度血小板减少症的最高风险（RR8.69，p <0.01）。血小板减少性先兆子痫或HELLP综合征与早产率最高相关（RR7.97，p0.00，分别为12.32）。血小板减少症也是低出生体重新生儿的危险因素，尤其是重度血小板减少症2047.50±938.98g（p0.02），而对照组为3224.86±496.00g。再次，血小板减少先兆子痫与低出生体重新生儿显着相关（RR11.94，p0.00），中等体重为2462.05±794.54g，而血小板减少妊娠为2932.37±708.91g，分别为3224.86±496.00g（p0.00 ）。结论：孕妇的血小板减少症与围产期发病率相关，与子痫前期和HELLP综合征有关的早产和低出生体重之间的关联最强：血小板数越低，胎儿/新生儿的风险越高。因此，我们强烈建议对血小板减少症母亲及其婴儿进行密切监视，以便确定病因和最佳干预时机。

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