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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Carbetocin versus oxytocin to reduce additional uterotonic use at non-elective caesarean section: a double-blind, randomised trial
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Carbetocin versus oxytocin to reduce additional uterotonic use at non-elective caesarean section: a double-blind, randomised trial

机译：Carbetocin与催产素可减少非选择性剖宫产术中宫缩剂的使用：一项双盲，随机试验

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Objective: We compared the efficacy of Carbetocin (long-acting oxytocin receptor agonist) versus Oxytocin given at non-elective caesarean section.Method: We performed a double-blind, randomised, single-centre study. Eligible women were37 weeks of gestation undergoing emergency caesarean section. Participants received either carbetocin of 100g or oxytocin 5 international units. The primary outcome was the need to administer additional uterotonics, as determined by the clinician. Secondary outcomes included estimated blood loss, haemoglobin drop pre-post operation and the need for a blood transfusionResults: From August 2012 to February 2013, 114 women were enroled. Two were excluded from analysis as they received a general anaesthetic. Fifty-nine patients received 100-g carbetocin; 53 received 5 international units oxytocin. There was no statistically significant difference in the number of women requiring additional uterotonics between the two groups: Carbetocin group 22% and Oxytocin group 13% (p=0.323). There were no significant differences in the fall in haemoglobin, estimated blood loss, rates of post-partum haemorrhage or blood transfusions.Conclusion: Oxytocin and carbetocin have similar requirements for additional uterotonics, estimated blood loss, haemoglobin drop and blood transfusions. There was a trend towards requiring additional uterotonics in patients receiving Carbetocin which was not statistically significant. This study found no benefits in using carbetocin over oxytocin.
机译：目的：我们比较了非选择性剖宫产术中长效催产素受体激动剂卡比妥与催产素的疗效。方法：我们进行了一项双盲，随机，单中心研究。符合条件的妇女在妊娠37周后接受了紧急剖腹产。参与者获得了100g卡贝托星或5个国际单位催产素。主要结果是需要由临床医生确定是否需要使用其他子宫内避孕药。次要结果包括估计的失血量，术前血红蛋白下降和输血的必要性。结果：2012年8月至2013年2月，有114名妇女入组。由于接受了全身麻醉，因此将两名患者排除在分析之外。 59例患者接受了100克卡比妥星; 53个接受了5个国际单位催产素。两组之间需要额外的子宫收缩剂的女性人数在统计学上没有显着差异：卡贝托星组为22％，催产素组为13％（p = 0.323）。血红蛋白下降，估计失血量，产后出血率或输血率无显着差异。结论：催产素和卡宾霉素对额外的子宫收缩剂，估计失血量，血红蛋白下降和输血的需求相似。有趋势，在接受卡波霉素治疗的患者中需要额外的子宫收缩剂，但无统计学意义。这项研究发现，使用催产素比使用催产素没有任何好处。

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