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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >The common vaginal commensal bacterium Ureaplasma parvum is associated with chorioamnionitis in extreme preterm labor
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The common vaginal commensal bacterium Ureaplasma parvum is associated with chorioamnionitis in extreme preterm labor

机译：在极端早产中常见的阴道共生细菌小支气管炎与绒毛膜羊膜炎有关

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摘要

Objective: To assess the association of vaginal commensal and low-grade pathogenic bacteria including Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis, Mycoplasma genitalium, Group B streptococcus (GBS), and Gardnerella vaginalis, in women who delivered preterm at less than 37-week gestation in the presence or absence of inflammation of the chorioamnionitic membranes.Methods: A case control study involving women who delivered before 37-week gestation with and without inflammation of chorioamnionitic membranes. A total of 57 placental samples were histologically examined for polymorphonuclear leukocyte infiltration of placental tissue for evidence of chorioamnionitis, and by type-specific nucleic acid amplification for evidence of infection with one or more of the target bacteria. Demographic data were collected for each mother.Results: Among the 57 placental samples, 42.1% had chorioamnionitis and 24.6% delivered in the second trimester of pregnancy; U. parvum, U. urealyticum, G. vaginalis, and GBS were all detected in the study with respective prevalence of 19.3%, 3.5%, 17.5%, and 15.8%; M. genitalium and M. hominis were not detected. U. parvum was significantly associated with chorioamnionitis (p=0.02; OR 5.0; (95% CI 1.2-21.5) and was more common in women who delivered in the second (35.7%) compared to the third trimester of pregnancy (13.9%). None of the other bacteria were associated with chorioamnionitis or earlier delivery, and all G. vaginalis-positive women delivered in the third trimester of pregnancy (p = 0.04).Conclusions: The detection of U. parvum in placental tissue was significantly associated with acute chorioamnionitis in women presenting in extreme preterm labor.
机译：目的：评估在早产时间少于37周的妇女中，阴道共通性和低度致病菌（包括细小支原体，解脲支原体，人型支原体，生殖器支原体，B组链球菌（GBS）和阴道加德纳菌）之间的关系。方法：病例对照研究涉及在妊娠37周之前分娩的有无羊膜羊膜炎的妇女。总共对57个胎盘样品进行了组织学检查，以检查胎盘组织中是否有多形核白细胞浸润，以证明绒毛膜羊膜炎，并通过类型特异性核酸扩增检查是否感染了一种或多种目标细菌。结果：在57个胎盘样本中，有42.1％患有绒毛膜羊膜炎，在妊娠中期分娩的比例为24.6％。在该研究中检出了U. parvum，解脲脲原体，G。阴道菌和GBS，其患病率分别为19.3％，3.5％，17.5％和15.8％;未检测到生殖器支原体和人支原体。 U. parvum与绒毛膜羊膜炎显着相关（p = 0.02; OR 5.0;（95％CI 1.2-21.5），与妊娠中期（13.9％）相比，第二胎（35.7％）分娩的女性更为普遍。其他细菌均无绒毛膜羊膜炎或较早分娩，所有阴道加德纳氏菌阳性的妇女均在妊娠中期分娩（p = 0.04）。极端早产妇女的急性绒毛膜羊膜炎。

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