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首页> 外文期刊>The Journal of maternal-fetal medicine >Acute fetal asphyxia and permanent brain injury: a retrospective analysis of current indicators.
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Acute fetal asphyxia and permanent brain injury: a retrospective analysis of current indicators.

机译：急性胎儿窒息和永久性脑损伤：当前指标的回顾性分析。

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OBJECTIVE: To determine whether a term neonate who has had sufficient intrapartum asphyxia to produce persistent brain injury will manifest the following four criteria: profound acidemia (arterial pH <7.00), an APGAR score < or =3 for 5 min or longer, seizures within 24 h of birth, and multiorgan system dysfunction. METHODS: Singleton, liveborn, neurologically impaired neonates > or =37 weeks gestation who lived at least 6 days and had sufficient documentation of current intrapartum asphyxia criteria were retrospectively analyzed. Of these infants, solely neonates with acute fetal asphyxia due to a sudden prolonged FHR deceleration that lasted until delivery from a catastrophic event, e.g., uterine rupture, cord prolapse, were included. Organ system dysfunction was defined by separate criteria for each organ system. Dysfunction in one or more was defined as multiorgan system dysfunction. RESULTS: Of the 292 eligible infants in the registry, 47 satisfied the entry criteria. In these 47 neonates, 10 (21%) satisfied all 4 criteria for intrapartum asphyxia. CONCLUSIONS: Our retrospective study suggests that currently used indicators to define permanent fetal brain injury are not valid.
机译：目的：确定足月产后窒息足以引起持续性脑损伤的足月新生儿是否会表现出以下四个标准：严重酸血症（动脉pH <7.00），APGAR评分<或= 3（持续5分钟或更长时间），出生24小时内，多器官系统功能障碍。方法：回顾性分析≥6周胎龄≥37周，单胎，活产，神经功能受损的新生儿，他们至少活了6天，并且有足够的文献证明了目前的产时窒息标准。在这些婴儿中，仅包括由于突然延长的FHR减速而导致的急性胎儿窒息的新生儿，这种减速持续到灾难性事件（例如子宫破裂，脐带脱垂）分娩为止。器官系统功能障碍是由每个器官系统的独立标准定义的。一个或多个中的功能障碍定义为多器官系统功能障碍。结果：在登记的292名合格婴儿中，有47名符合入围标准。在这47例新生儿中，有10例（21％）满足了所有4项围产期窒息标准。结论：我们的回顾性研究表明，目前用于确定永久性胎儿脑损伤的指标无效。

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