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首页> 外文期刊>The Journal of Comparative Neurology >Relationship between laminar topology and retinotopy in the rhesus lateral geniculate nucleus: results from a functional atlas.
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Relationship between laminar topology and retinotopy in the rhesus lateral geniculate nucleus: results from a functional atlas.

机译：层状拓扑与恒河猴外侧膝状核的视网膜检影之间的关系：来自功能性图谱的结果。

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The primary focus of this paper is the abrupt transition that occurs midway through the rhesus lateral geniculate nucleus (LGN) from six layers posteriorly (conventionally numbered 1-6, ventral to dorsal) to four layers anteriorly. At this transition, layers 4 and 6 fuse into a single layer, as do layers 3 and 5, requiring an inversion of the stacking order of the cell categories making up layers 4 and 5. To understand the topology of this transition and its relationship to geniculate retinotopy, we have created a functional atlas of a rhesus LGN that affords three-dimensional views of morphology and retinotopy at a resolution of 25 microm. The projection of the path of the transition into visual space is highly biased toward lower visual fields, intersecting the upper vertical meridian at 6.4 degrees , the horizonal meridian at 15.4 degrees, and the lower vertical meridian at 25.0 degrees. Between inclinations of -31 degrees and 55 degrees, layers 3 and 5 merge through an elongated tear in layer 4 that subsumes the optic disk gap and extends medially and laterally; elsewhere, layers 4 and 6 merge through a tear in layer 5. These tears cause substantial violations of retinotopy and laminar integrity, so the inversion of layers 4 and 5 requires that the forces establishing retinotopy and grouping by cell class be locally overcome during morphogenesis. The transition and associated tears are evaluated in the context of recent computational models of geniculate morphogenesis. We have also used the atlas to estimate the borders of the binocular (55 approximately 62 degrees) and monocular (91 approximately 97 degrees) visual fields. Files containing the atlas are made publicly available on a website.
机译：本文的主要重点是在恒河猴外侧膝状核（LGN）的中途从后六层（通常编号为1-6，腹侧至背侧）突然过渡到前四层。在此过渡中，第4层和第6层与第3层和第5层一样融合为单层，需要颠倒构成第4层和第5层的电池类别的堆叠顺序。要了解此过渡的拓扑结构及其与膝状视网膜检影，我们创建了一个恒河猴LGN功能图集，以25微米的分辨率提供了形态学和视网膜检影的三维视图。过渡到视觉空间的路径的投影高度偏向较低的视野，与上垂直子午线相交于6.4度，与水平子午线相交于15.4度，而下垂直子午线相交于25.0度。在-31度和55度的倾斜度之间，第3层和第5层通过第4层中的细长裂缝合并在一起，该裂缝包含了视盘间隙并在内侧和外侧延伸。在其他地方，第4层和第6层通过第5层的撕裂合并在一起。这些撕裂严重破坏了视网膜和层状完整性，因此第4层和第5层的倒置要求在形态发生过程中局部克服建立视网膜和按细胞类别分组的力。在膝状形态发生的最新计算模型的背景下评估过渡和相关的眼泪。我们还使用了地图集来估计双目（55个约62度）和单眼（91个约97度）视野的边界。包含图集的文件可在网站上公开获得。

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