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首页> 外文期刊>The Journal of Comparative Neurology >Positive emotions and brain reward circuits in chronic pain
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Positive emotions and brain reward circuits in chronic pain

机译:慢性疼痛中的积极情绪和大脑奖励回路

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Chronic pain is an important public health problem that negatively impacts the quality of life of affected individuals and exacts enormous socioeconomic costs. Chronic pain is often accompanied by comorbid emotional disorders including anxiety, depression, and possibly anhedonia. The neural circuits underlying the intersection of pain and pleasure are not well understood. We summarize recent human and animal investigations and demonstrate that aversive aspects of pain are encoded in brain regions overlapping with areas processing reward and motivation. We highlight findings revealing anatomical and functional alterations of reward/motivation circuits in chronic pain. Finally, we review supporting evidence for the concept that pain relief is rewarding and activates brain reward/motivation circuits. Adaptations in brain reward circuits may be fundamental to the pathology of chronic pain. Knowledge of brain reward processing in the context of pain could lead to the development of new therapeutics for the treatment of emotional aspects of pain and comorbid conditions. J. Comp. Neurol. 524:1646-1652, 2016. (c) 2016 Wiley Periodicals, Inc.
机译:慢性疼痛是一个重要的公共卫生问题,会对受影响的人的生活质量产生负面影响,并带来巨大的社会经济成本。慢性疼痛通常伴有合并症,包括焦虑症,抑郁症和可能的快感不足。疼痛和愉悦交集的神经回路尚未得到很好的理解。我们总结了最近的人类和动物研究,并证明疼痛的厌恶方面是在与处理奖励和动机的区域重叠的大脑区域编码的。我们强调发现揭示慢性疼痛中奖赏/动机回路的解剖学和功能改变。最后,我们回顾了缓解疼痛有益并激活大脑奖励/动机回路这一概念的支持证据。脑奖赏回路的适应可能是慢性疼痛病理的基础。在疼痛的背景下对大脑奖赏过程的了解可能会导致开发新的疗法来治疗疼痛和合并症的情感方面。 J.比较神经元。 524:1646-1652,2016.(c)2016威利期刊公司

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