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首页> 外文期刊>Chinese journal of digestive diseases >The roles of vitamin C in Helicobacter pylori associated gastric carcinogenesis.
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The roles of vitamin C in Helicobacter pylori associated gastric carcinogenesis.

机译：维生素C在幽门螺杆菌相关的胃癌发生中的作用。

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摘要

Ascorbic acid, as one of the important water-soluble vitamins, is essential for a range of physiological functions, including the syntheses of collagen, carnitine and neurotransmitters. It is also an important dietary antioxidant against oxidative stress. Current information suggests that vitamin C might be protective against the development of gastric cancer. Chronic infection with Helicobacter pylori is recognized to be a significant cause of gastric adenocarcinoma. Inflammation induced by H. pylori infection in the stomach not only causes significantly enhanced consumption of vitamin C, but also reduces secretion of the vitamin into the gastric lumen. Most of the evidence relating to vitamin C and H. pylori infection derives from clinical studies and experiments directly examining the effect of vitamin C on H. pylori-associated gastric carcinogenesis and remains limited. Furthermore, results from recent studies suggest that vitamin C might also increase the risk of cancer through its pro-oxidant activity and protect against oxidative stress in cancer cells through its antioxidant action. In this article we review recent publications on vitamin C research and assess the potential roles of vitamin C in H. pylori associated gastric carcinogenesis. The possible adverse effects of the vitamin C are also discussed.
机译：抗坏血酸是一种重要的水溶性维生素，对于一系列生理功能至关重要，包括胶原蛋白，肉碱和神经递质的合成。它也是抵抗氧化应激的重要饮食抗氧化剂。目前的信息表明维生素C可能对胃癌的发展具有保护作用。幽门螺杆菌的慢性感染被认为是胃腺癌的重要原因。由胃中的幽门螺杆菌感染引起的炎症不仅导致维生素C的消耗显着增加，而且还减少了维生素向胃腔的分泌。有关维生素C和幽门螺杆菌感染的大多数证据来自临床研究和实验，这些研究和实验直接检查了维生素C对幽门螺杆菌相关胃癌发生的作用，并且仍然有限。此外，最近的研究结果表明，维生素C还可能通过其前氧化活性而增加患癌症的风险，并通过其抗氧化作用来抵抗癌细胞中的氧化应激。在本文中，我们回顾了有关维生素C研究的最新出版物，并评估了维生素C在幽门螺杆菌相关胃癌发生中的潜在作用。还讨论了维生素C的可能的不利影响。

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