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首页> 外文期刊>Chinese journal of digestive diseases >Comparison of the efficacy of 1-day high-dose quadruple therapy versus 7-day triple therapy for treatment of Helicobacter pylori infection.
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Comparison of the efficacy of 1-day high-dose quadruple therapy versus 7-day triple therapy for treatment of Helicobacter pylori infection.

机译：1天大剂量四联疗法与7天三联疗法治疗幽门螺杆菌感染的疗效比较。

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BACKGROUND: The proton pump inhibitor (PPI)-based 7-day triple therapy is the regimen with the highest cure rates for eradication of Helicobacter pylori infection and has been recommended as the first-line regimen in the world. It had been reported that a 1-day quadruple therapy could also successfully cure 95% of the H. pylori infected patients. OBJECTIVES: To observe the efficacy of 1-day high-dose quadruple therapy versus 7-day triple therapy for treatment of H. pylori infection, and to observe side-effects of the two different regimens. METHODS: This randomized, open, parallel-controlled study was conducted at Renji Hospital between November 2004 to March 2005. A total of 80 consecutive patients with non-ulcer dyspepsia, who were H. pylori positive proven by both rapid urease test and histology were included and randomly assigned to 1-day quadruple therapy or 7-day triple therapy. Thirty-nine patients were administered with 1-day high-dose quadruple therapy including esomeprazole 40 mg b.i.d., colloidal bismuth subcitrate 440 mg q.i.d., amoxicillin 2 g q.i.d. and metronidazole (400 mg q.i.d.) for 1 day. Forty-one patients received a standard 7-day triple therapy consisting of esomeprazole 20 mg b.i.d., clarithromycin 500 mg b.i.d. and amoxicillin 1 g b.i.d. for 7 days. The eradication rates were evaluated by the (13)C-urea breath test at least 4 weeks after completion of a course treatment. RESULTS: Seventy-seven patients completed the trial and three patients dropped out. The eradication rates in the 1-day therapeutic group and the 7-day therapeutic group were 39.5% (15/38) and 84.6% (33/39), respectively. There was a statistically significant difference between the two groups (P < 0.0001). Short-lasting and self-limiting side effects including thirst, a metallic taste, diarrhea and abdominal pain were reported in three patients (7.9%) in the 1-day group and seven patients (18%) in the 7-day group (P = 0.31). CONCLUSIONS: A 1-day high-dose quadruple therapy with amoxicillin, metronidazole, bismuthsalt, and esomeprazole is not effective for eradication of H. pylori compared with the standard 7-day triple therapy.
机译：背景：基于质子泵抑制剂（PPI）的7天三联疗法是根除幽门螺杆菌感染治愈率最高的疗法，并已被推荐为世界上的一线疗法。据报道，为期1天的四联疗法也可以成功治愈95％的幽门螺杆菌感染患者。目的：观察1天大剂量四联疗法和7天三联疗法治疗幽门螺杆菌感染的疗效，并观察两种不同方案的副作用。方法：该随机，开放，平行对照研究于2004年11月至2005年3月间在仁济医院进行。共80例连续的非溃疡性消化不良患者，经快速尿素酶检测和组织学检查均证实为幽门螺杆菌阳性。并随机分配为1天四联疗法或7天三联疗法。对三十九名患者进行了为期1天的大剂量四联疗法治疗，包括依索美拉唑40 mg b.i.d.，胶体次柠檬酸铋铋440 mg q.i.d.，阿莫西林2 g q.i.d.和甲硝唑（400 mg q.i.d.）1天。 41名患者接受了标准的7天三联疗法，包括每天20 mg的埃索美拉唑，每天500 mg的克拉霉素。和阿莫西林1 g b.i.d. 7天。疗程结束后至少4周通过（13）C-尿素呼气试验评估根除率。结果：77位患者完成了试验，三位患者退出了研究。 1天治疗组和7天治疗组的根除率分别为39.5％（15/38）和84.6％（33/39）。两组之间有统计学差异（P <0.0001）。在第1天组中有3例（7.9％），在第7天组中有7例（18％）报告了持续且自我限制的副作用，包括口渴，金属味，腹泻和腹痛（P = 0.31）。结论：与标准的7天三联疗法相比，阿莫西林，甲硝唑，铋盐和埃索美拉唑为期1天的大剂量四联疗法对根除幽门螺杆菌无效。

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