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首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming.
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CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming.

机译：CpG寡脱氧核苷酸可以绕过新生儿对疫苗的Th2反应极化，但可能无法完全重定向由新生儿初免建立的Th2反应。

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摘要

Neonatal murine responses to a panel of conventional vaccines differ qualitatively from adult responses by a particular polarization toward a Th2 pattern and a frequent limitation of the Th1 and CTL responses required for protection against intracellular microorganisms. In contrast, DNA vaccines induce adult-like Th1/CTL neonatal responses against the same vaccine Ags. In this report, we show that this can be related to their content in unmethylated CpG motifs. Oligodeoxynucleotides (ODN) containing CpG motifs activate neonatal APCs to produce IL-12 in vitro and induce adult-like Th1 responses to tetanus toxoid and measles Ags in vivo, with production of IgG2a-specific Abs and adult-like secretion of IFN-gamma and IL-5 by Ag-specific T cells. However, in spite of their capacity to trigger neonatal B cell proliferation in vitro, CpG-ODN only partially enhanced early life Ab responses. Finally, using Th1-driving CpG-ODN with the boosting dose of a protein vaccine was sufficient to redirect adult but not neonatally primed Th2 responses. These observations could be important for the development of novel vaccines that will have to be effective early in life.
机译：新生鼠对一组常规疫苗的反应在质量上与成年反应不同，其对Th2型的特殊极化和对细胞内微生物的保护所需要的Th1和CTL反应的频繁限制。相反，DNA疫苗诱导针对相同疫苗Ags的成人样Th1 / CTL新生儿反应。在这份报告中，我们表明这可能与它们在未甲基化的CpG图案中的含量有关。含有CpG基序的寡脱氧核苷酸（ODN）在体外激活新生儿APC以产生IL-12，并在体内诱导成年状对破伤风类毒素和麻疹Ag的Th1反应，产生IgG2a特异性抗体和成年状的IFN-γ分泌。 Ag特异的T细胞产生IL-5。但是，尽管CpG-ODN具有体外触发新生儿B细胞增殖的能力，但仅能部分增强其早期Ab反应。最后，将Th1驱动的CpG-ODN与增强剂量的蛋白疫苗一起使用足以重定向成人，但不能重定向新生儿引发的Th2反应。这些观察对于开发必须在生命早期有效的新型疫苗可能很重要。

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