Mast cells and neuropeptidergic terminals: Experimental studies of the mechanism of visceral hypersensitivity in irritable bowel syndrome

Zhao Shen LI; Wen Zhu DONG; Duo Wu ZOU; Xiao Ping ZOU; Guo Ming XU; Ai Yong ZHU

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Mast cells and neuropeptidergic terminals: Experimental studies of the mechanism of visceral hypersensitivity in irritable bowel syndrome

机译：肥大细胞和神经肽末梢：肠易激综合征内脏超敏反应机理的实验研究

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OBJECTIVE: The failure of dysmotility to explain the symptoms of pain in irritable bowel syndrome (IBS) led to studies on visceral hypersensitivity. Mucosal mast cells (MC) may be one factor influencing the response of visceral afferents to mechanical and chemical stimuli because they are found in close proximity to gastrointestinal mucosal sensory nerve terminals containing neuropeptides and a bi-directional pathway linking the central nervous system, gut and MC has been demonstrated.

机译：目的：运动障碍不能解释肠易激综合征（IBS）的疼痛症状，导致对内脏超敏反应的研究。粘膜肥大细胞（MC）可能是影响内脏传入器官对机械和化学刺激反应的因素之一，因为它们紧邻包含神经肽和连接中枢神经系统，肠道和肠道的双向途径的胃肠道粘膜感觉神经末梢。 MC已经被证明。

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来源
《Chinese journal of digestive diseases》 |2003年第3期|共7页
作者
Zhao Shen LI; Wen Zhu DONG; Duo Wu ZOU; Xiao Ping ZOU; Guo Ming XU; Ai Yong ZHU;
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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
irritable bowel syndrome; mast cell; neuropeptidergic terminal; hypersensitivity;

机译：肠易激综合征;肥大细胞;神经肽末梢;超敏反应;

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1. Mast cells and neuropeptidergic terminals: Experimental studies of the mechanism of visceral hypersensitivity in irritable bowel syndrome [J] . Zhao Shen LI, Wen Zhu DONG, Duo Wu ZOU, Chinese journal of digestive diseases . 2003,第3期

机译：肥大细胞和神经肽末梢：肠易激综合征内脏超敏反应机理的实验研究
2. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. [J] . Klooker TK, Braak B, Koopman KE, Gut: Journal of the British Society of Gastroenterology . 2010,第9期

机译：肥大细胞稳定剂酮替芬可降低肠易激综合症患者的内脏超敏反应并改善肠道症状。
3. Ameliorating effects of sacral nerve stimulation for visceral hypersensitivity and mechanisms involving nerve growth factor and TRPV1 in rats with irritable bowel syndrome [J] . Neurogastroenterology and motility . 2019,第S3期

机译：骶神经刺激对易激肠综合征大鼠神经生长因子和TRPV1涉及神经生长因子和TRPV1的机制的改善作用
4. Role of Anger and Coping Mechanisms in Patients with Irritable Bowel Syndrome [C] . Fadgyas Stanculete M., Pojoga C., Dumitrascu D.L. European Association of Psychosomatic Medicine., Annual Meeting. . 2014

机译：肠易激综合征患者愤怒和应对机制的作用
5. Lactobacillus reuteri reduces visceral hypersensitivity and alters gut motility without changing gut serotonin availability in an animal model of the irritable bowel syndrome. [D] . Jakupovic, Jasmina. 2013

机译：在肠易激综合征的动物模型中，路氏乳杆菌可降低内脏超敏反应并改变肠蠕动，而不会改变肠内5-羟色胺的利用率。
6. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome [O] . Bin Feng, Jun Ho La, Erica S. Schwartz, -1

机译：肠易激综合征内脏超敏反应的神经和神经免疫机制
7. Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Methods to assess visceral hypersensitivity in irritable bowel syndrome. [O] . Keszthelyi D., Troost F.J., Masclee A.A.M. 2012

机译：肠易激综合征：方法，机制和病理生理学。评估肠易激综合征内脏超敏反应的方法。

Mast cells and neuropeptidergic terminals: Experimental studies of the mechanism of visceral hypersensitivity in irritable bowel syndrome

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